Outcome comparison of treatment of brain metastases in hypofractionation and staged radiosurgery

Abstract

Brain metastases occur in 20–40% of cancer patients. The main methods of treatment are neurosurgical intervention, radiation therapy, and stereotactic radiosurgery is actively developing. The advantage of radiosurgery is non-invasiveness, the effectiveness of exposure to foci and the low probability of radiation reactions after treatment. However, in patients with a tumor volume exceeding 3 centimeters in diameter, with radiosurgical doses (>18 Gy), the risk of post-radiation complications is subsequently high, therefore radiosurgical methods of hypofractionation and staged radiosurgery are increasingly used. The research included a group of patients (46 people) who underwent treatment by the method of staged radiosurgery and a group of patients (27 people) who underwent hypofractionation. The clinical study was conducted at the Leksell Gamma Knife Icon installation (Stockholm, Sweden). The summed dose was in the range from 16 to 30 Gy. The purpose of research: to study and compare the results of the use of hypofractionation methods and staged radiosurgery for brain metastases.