{"title":"Biophysical neural spiking and bursting dynamics in reconfigurable analog VLSI","authors":"Theodore Yu, T. Sejnowski, G. Cauwenberghs","doi":"10.1109/BIOCAS.2010.5709602","DOIUrl":null,"url":null,"abstract":"We study a range of neural dynamics under variations in biophysical parameters implementing extended Morris-Lecar and Hodgkin-Huxley models in three gating variables. The dynamics are emulated in NeuroDyn, an analog VLSI programmable neural emulation platform with generalized channel kinetics and biophysical membrane dynamics. We present simulation and measurement results and observe consistent agreement over a wide regime of tonic spiking and intrinsic bursting dynamics through the variation of a single conductance parameter governing calcium recovery.","PeriodicalId":440499,"journal":{"name":"2010 Biomedical Circuits and Systems Conference (BioCAS)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2010 Biomedical Circuits and Systems Conference (BioCAS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIOCAS.2010.5709602","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
We study a range of neural dynamics under variations in biophysical parameters implementing extended Morris-Lecar and Hodgkin-Huxley models in three gating variables. The dynamics are emulated in NeuroDyn, an analog VLSI programmable neural emulation platform with generalized channel kinetics and biophysical membrane dynamics. We present simulation and measurement results and observe consistent agreement over a wide regime of tonic spiking and intrinsic bursting dynamics through the variation of a single conductance parameter governing calcium recovery.