Correlation of CD4+ T cell count with serum Zinc, Copper and Selenium in HIV positive individuals

A. Malviya, H. Hasan, A. Hussain
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引用次数: 12

Abstract

The basic role of micronutrients in the pathogenesis of HIV infection still remains a major lacuna in scientific knowledge. Hence, the present study was carried out with an objective to documentMean level of serum Zinc, Copper and Selenium in patients with HIV infection vis-a-vis healthy controls, and also to find, Correlation of CD4+T cell count with serum Zinc, Copper and Selenium in HIV infected individuals This case-control study was carried out with 50 subjects in either arm matched for age and sex. Cases were patients tested positive for HIV by ELISA using two different antigens whereas the controls were healthy subjects. The mean serum level of Zinc shows a positive correlation with CD4 cell count. The serum Se levels declined progressively with falling CD4 cell counts (p<.001). Zn and Se supplementation can be used as a boost in standardized HAART therapy and nutritional programs for HIV positive patients.
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HIV阳性个体CD4+ T细胞计数与血清锌、铜、硒的相关性
微量营养素在HIV感染发病机制中的基本作用仍然是科学知识的一个重大空白。因此,本研究的目的是记录HIV感染者血清锌、铜和硒的平均水平,并发现CD4+T细胞计数与HIV感染者血清锌、铜和硒的相关性。本病例对照研究在年龄和性别匹配的两组各50名受试者中进行。病例为用两种不同抗原ELISA检测HIV阳性的患者,对照组为健康受试者。血清锌平均水平与CD4细胞计数呈正相关。血清硒水平随着CD4细胞计数的下降而逐渐下降(p< 0.001)。锌和硒补充剂可用于促进艾滋病毒阳性患者的标准化HAART治疗和营养计划。
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