[Low-molecular heparin complex formation with the blood coagulation proteins--thrombin and fibrinogen].

B A Kudriashov, L A Liapina, V E Pastorova, M V Kondashevskaia
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Abstract

It has been found that low molecular heparin (LMH) forms complexes with fibrinogen and thrombin. The formation of the heparin-fibrinogen and heparin-thrombin complexes has been testified by cross-linked electrophoresis. The reaction of complex formation was carried out at variable weight ratios of the components, i.e. 1:3 and 1:6, respectively. This complex causes lysis of unstabilized clots of fibrin. All these complexes manifested a slight anticoagulative activity.

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[低分子肝素复合物与凝血蛋白——凝血酶和纤维蛋白原的形成]。
研究发现,低分子肝素与纤维蛋白原和凝血酶形成复合物。交联电泳证实了肝素-纤维蛋白原和肝素-凝血酶复合物的形成。在不同组分的质量比(分别为1:3和1:6)下进行络合物生成反应。这种复合物导致不稳定的纤维蛋白凝块的溶解。这些复合物均表现出轻微的抗凝活性。
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