[Adaptation to chemical mutagens].

Izvestiia Akademii nauk SSSR. Seriia biologicheskaia Pub Date : 1992-09-01

I V Serebriakova, M M Fomina, G G Poroshenko

引用次数: 0

Abstract

Pre-adaptation of normal and tumor cells to the action of methylnitrosourea was studied. To attain these ends, a single low dose (10 mg/kg) was administered to animals two hours prior to the administration of main therapeutic dose (100 mg/kg) and the number of chromosomal rearrangements was determined. A significant decrease in translocation incidence was observed in metaphases of Ehrlich-ICP ascitic strain. Similar results were obtained on cells of murine bone marrow. The mechanisms of pre-adaptation to the action is discussed.

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[对化学诱变剂的适应]。

研究了正常细胞和肿瘤细胞对甲基亚硝基脲作用的预适应。为了达到这些目的，在给予主治疗剂量(100 mg/kg)前2小时给予动物单次低剂量(10 mg/kg)，并测定染色体重排的数量。在Ehrlich-ICP腹水毒株的中期，易位发生率显著降低。在小鼠骨髓细胞上也得到了类似的结果。讨论了对动作的预适应机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Izvestiia Akademii nauk SSSR. Seriia biologicheskaia

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