[The safety problem and a physiological strategy for using glucocorticoid hormones].

L A Piruzian, I T Rass
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Abstract

Principal problems of glucocorticoid hormone application in non-endocrine diseases are discussed proceeding from the mechanism of their action and the role in organism's life. It appeared that the hazard of glucocorticoid therapy is mainly due to the absence of a test for sufficiency and real needs in these hormones. It was shown that the test has to be introduced reflecting on the whole body level the glucocorticoid activity in the cell, that is similar to blood glucose in relation to insulin. The introduction of free blood tyrosine as such test appears to allow the development of safe individual strategy for the usage of glucocorticoids.

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[使用糖皮质激素的安全问题和生理策略]。
从糖皮质激素的作用机制及其在生物生命中的作用入手,讨论了糖皮质激素在非内分泌疾病中应用的主要问题。看来,糖皮质激素治疗的危害主要是由于缺乏对这些激素的充足性和实际需求的测试。研究结果表明,必须引入反映细胞中糖皮质激素活性的全身水平的测试,这类似于血糖与胰岛素的关系。引入游离血酪氨酸作为这样的测试似乎允许开发安全的个人策略使用糖皮质激素。
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