[New biologically active substances from protozoa and an evaluation of their action].

N N Sukhareva, V M Uriniuk, M M Viadro, S M Navashin
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Abstract

Novel biologically active substances were obtained from nonpathogenic for humans and free-living protozoa: Crithidia oncopelti, Trypanosoma lewisi, and Astasia longa. There were studied conditions of biosynthesis, composition and biological activity of the total lipid fraction from the protozoa species, sucrose ethers and fatty acids, the latter were isolated from A. longa--(astazilide preparation), reserve beta-1,3 glucan from A. longa (astazian preparation), and fraction of surface glycophospholipids and peptides from Crithidia oncopelti (GLP preparation). Two of three preparations studied (astazilide and GLP) are the complexes of natural substances with certain composition. Conditions of the protozoa cultivation were developed to provide standardization of the complex composition. Division of the complexes into separate components decreased or abolished the biological activity. It was established that the substances studied modify biological reactions, that is exert a systemic effect. They may be used for inhibiting the growth of experimental tumors and preventing the metastatic spreading in tumor-carrier animals. The substances obtained belong to the group of nonspecific stimulators for cellular immunity which can be used in medicine, veterinary medicine, food industry, pharmacologic industry and cosmetology.

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[来自原生动物的新的生物活性物质及其作用的评价]。
从对人类和自由生活的非致病性原生动物中获得了新的生物活性物质:冠棘虫、刘易斯锥虫和长亚洲Astasia。研究了原生动物总脂质组分、糖醚和脂肪酸的合成条件、组成和生物活性,后者分别从龙竹中分离得到(阿司他利特制剂)、龙竹中分离得到(阿司他利特制剂)储备β -1,3葡聚糖,以及龙竹中表面糖磷脂和多肽的组分(GLP制剂)。所研究的三种制剂中有两种(阿司他利特和GLP)是具有一定组成的天然物质的配合物。开发了原生动物培养条件,以提供复杂成分的标准化。复合物分裂成单独的组分降低或消除了生物活性。研究表明,所研究的物质可以改变生物反应,即发挥全身作用。它们可用于抑制实验性肿瘤的生长和防止肿瘤载体动物的转移扩散。所得物质属于细胞免疫非特异性刺激物,可用于医药、兽药、食品、制药、美容等行业。
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