[The dependence of the cytokinetic effects of alkylating antitumor preparations on the phase of the hepatocyte cell cycle in regenerating liver].

I V Uryvaeva, A S Sokolov, S G Kalistratov, G V Delone
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Abstract

Effects of alkylating antitumor drugs on resting (G0 phase of cell cycle) and proliferating (G1, S, G2 and M phases) hepatocytes were studied in regenerating mouse liver. Cell cycle kinetics (fraction of labeled mitoses, labeling and mitotic indices) were determined by 3H-thymidine autoradiography. Dipin and fotrin as a DNA-damaging agents attack mainly resting (G0) and proliferating (G1) cells. Effect of the damage results in the inhibition of DNA synthesis and G2 phase arrest in the following mitotic cycle. An alkylating drug phopurin as well as ara-C both suppress the mitotic progression in proliferating hepatocytes and do not influence the resting cells.

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[烷基化抗肿瘤制剂的细胞动力学作用对再生肝脏肝细胞周期阶段的依赖性]。
研究了烷基化抗肿瘤药物对再生小鼠肝脏静息期(细胞周期G0期)和增殖期(G1、S、G2和M期)肝细胞的影响。细胞周期动力学(标记有丝分裂的比例,标记和有丝分裂指数)通过3h -胸腺嘧啶放射自显像测定。Dipin和fotrin作为dna损伤剂主要攻击静止(G0)和增殖(G1)细胞。损伤的影响导致DNA合成的抑制和G2期在随后的有丝分裂周期中停滞。烷基化药物磷嘌呤和ara-C都抑制增殖肝细胞的有丝分裂进程,而不影响静息细胞。
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