Effects of Inositol in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Kohsuke Hayamizu, Yui Kuramochi, A. Sumino, N. Izumo, Megumi Furukawa, M. Nakano
{"title":"Effects of Inositol in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Kohsuke Hayamizu, Yui Kuramochi, A. Sumino, N. Izumo, Megumi Furukawa, M. Nakano","doi":"10.15226/jnhfs.2022.001189","DOIUrl":null,"url":null,"abstract":"Background & Aims: To clarify the effects of treatment with inositol’s, D-chiro-inositol, myo-inositol, and pinitol, on hormonal and metabolic parameters in women with Polycystic Ovary Syndrome (PCOS), we conducted a systematic review and meta-analysis of recent randomized clinical trials of inositol’s in PCOS. Methods: The systematic review was conducted using data obtained from randomized controlled trials performed to assess the effects of inositol’s compared with placebo (UMIN000025843). The primary outcomes included serum insulin, HOMA index, sex hormones, and ovulation rate. Results: Eight studies involving 577 patients were eligible for systematic review. The meta-analysis results showed that compared with the control group, inositol’s may improve fasting insulin (Standardized Mean Difference (SMD) −1.06, 95% CI −1.83 to −0.29, p = 0.007), area under the curve (AUC) of Oral Glucose Tolerance Test (insulin SMD −0.76, 95% CI −1.20 to −0.32, p = 0.0008; glucose SMD −0.55, 95% CI −0.88 to −0.17, p = 0.004), free testosterone (SMD −1.94, 95% CI −3.28 to −0.61, p = 0.004), sex hormone binding globulin (SMD 1.10, 95% CI 0.37 to 1.82, p = 0.004), and ovulation rate (Risk Ratio 1.42, 95% CI −1.00 to 2.02, p = 0.05). Conclusions: Inositols may be effective for PCOS by improving insulin resistance. Keywords: Inositol, Polycystic ovary syndrome, Systematic review, Meta-analysis","PeriodicalId":366384,"journal":{"name":"Journal of Nutritional Health & Food Science","volume":"7 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutritional Health & Food Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15226/jnhfs.2022.001189","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Background & Aims: To clarify the effects of treatment with inositol’s, D-chiro-inositol, myo-inositol, and pinitol, on hormonal and metabolic parameters in women with Polycystic Ovary Syndrome (PCOS), we conducted a systematic review and meta-analysis of recent randomized clinical trials of inositol’s in PCOS. Methods: The systematic review was conducted using data obtained from randomized controlled trials performed to assess the effects of inositol’s compared with placebo (UMIN000025843). The primary outcomes included serum insulin, HOMA index, sex hormones, and ovulation rate. Results: Eight studies involving 577 patients were eligible for systematic review. The meta-analysis results showed that compared with the control group, inositol’s may improve fasting insulin (Standardized Mean Difference (SMD) −1.06, 95% CI −1.83 to −0.29, p = 0.007), area under the curve (AUC) of Oral Glucose Tolerance Test (insulin SMD −0.76, 95% CI −1.20 to −0.32, p = 0.0008; glucose SMD −0.55, 95% CI −0.88 to −0.17, p = 0.004), free testosterone (SMD −1.94, 95% CI −3.28 to −0.61, p = 0.004), sex hormone binding globulin (SMD 1.10, 95% CI 0.37 to 1.82, p = 0.004), and ovulation rate (Risk Ratio 1.42, 95% CI −1.00 to 2.02, p = 0.05). Conclusions: Inositols may be effective for PCOS by improving insulin resistance. Keywords: Inositol, Polycystic ovary syndrome, Systematic review, Meta-analysis
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肌醇对女性多囊卵巢综合征的影响:随机对照试验的系统回顾和荟萃分析
背景与目的:为了阐明肌醇、d -氨基肌醇、肌醇和蒎醇治疗对多囊卵巢综合征(PCOS)女性激素和代谢参数的影响,我们对最近的PCOS中肌醇的随机临床试验进行了系统回顾和荟萃分析。方法:采用随机对照试验的数据进行系统评价,以评估肌醇与安慰剂(UMIN000025843)的效果。主要结局包括血清胰岛素、HOMA指数、性激素和排卵率。结果:8项研究纳入577例患者,符合系统评价。meta分析结果显示,与对照组相比,肌醇可改善空腹胰岛素(标准化平均差值(SMD) - 1.06, 95% CI - 1.83 ~ - 0.29, p = 0.007),口服葡萄糖耐量试验曲线下面积(AUC)(胰岛素SMD - 0.76, 95% CI - 1.20 ~ - 0.32, p = 0.0008;葡萄糖SMD为- 0.55,95% CI为- 0.88 ~ - 0.17,p = 0.004),游离睾酮(SMD为- 1.94,95% CI为- 3.28 ~ - 0.61,p = 0.004),性激素结合球蛋白(SMD为1.10,95% CI为0.37 ~ 1.82,p = 0.004),排卵率(风险比1.42,95% CI为- 1.00 ~ 2.02,p = 0.05)。结论:肌醇可能通过改善胰岛素抵抗对PCOS有效。关键词:肌醇,多囊卵巢综合征,系统评价,meta分析
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Effects of Inositol in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials Sodium Levels in Pre-packaged Foods and Beverages Sold in Jamaica: A Label Analysis Vitamin D as a Preventive or Therapeutic Nutrient in COVID-19 Infection Bridging the Gap: Community Pharmacists’ Burgeoning Role as Point-Of-Care Providers During the COVID-19 Pandemic Through the Integration of Emerging Technologies Coronavirus-19 (Covid-19) Knowledge, and the Influence on Infants and Young Children Feeding Behaviors and Practices in the Mifi Health District, West Cameroon: Qualitative Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1