Regulatory long noncoding RNAs in cardiovascular development and congenital heart defects

Abstract

Long noncoding RNAs (lncRNAs) have emerged as potent regulators of cardiac development and can drive transcriptome programming, affecting all aspects of gene regulation. The functional properties of lncRNAs are notoriously diverse and have been mechanistically challenging. Thus, focused an efforts for lncRNA annotation and functional interrogation in these contexts is highly required. Herein, we discuss current approaches for identifying putative regulatory lncRNAs for the mechanistic investigation of their function in cardiovascular development and congenital heart defects (CHDs).