[The dose-dependent cytogenetic and growth-inhibiting effects of a new antitumor preparation from the nitrosourea group].

M M Fomina, Zh A Dzhamanbaev, L A Ostrovskaia
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Abstract

Kinetics of growth-inhibiting and cytogenetic effect of a new carbon-substituted nitrosourea derivative (ADEKO) has been studied in a wide dose range. A linear dose-effect dependence was observed. The level of damaged cells in a population is connected with a number of chromosomal aberrations per cells with a semilogarithmic dependence. The drug has a pronounced clastogenic effect that reveals itself in total damaging of chromosomal structure of tumor cells. It also causes cell polyploidization with the increase in does and duration of action. Chromosomal aberrations induced by the drug are observed in the tumor long after the action of the drug and their level correlates positively with antitumor activity of ADEKO. ADEKO damages preferentially tumor cells as compared to bone marrow.

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[亚硝基脲组新抗肿瘤制剂的剂量依赖性细胞遗传学和生长抑制作用]。
研究了一种新型碳取代亚硝基脲衍生物(ADEKO)在大剂量范围内的生长抑制动力学和细胞遗传学效应。观察到线性剂量效应依赖关系。一个群体中受损细胞的水平与每个细胞的染色体畸变数呈半对数依赖关系。该药具有明显的致裂作用,表现为肿瘤细胞染色体结构的完全破坏。随着剂量的增加和作用时间的延长,它也会引起细胞多倍体化。在药物作用后很长一段时间内,在肿瘤中观察到由药物引起的染色体畸变,其水平与ADEKO的抗肿瘤活性呈正相关。与骨髓相比,ADEKO优先损害肿瘤细胞。
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