Metastização uterina de carcinoma mamário – Relato de caso

Sílvia Couto , Carla Antunes , Ana Cristina Vilhena , Luís Canelas , Ana Oliveira
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Abstract

Metastatic disease involving the uterus is rare. Typically it is the ovaries that are involved and the primary tumor is usually the breast or the gastrointestinal tract.

Case report

We describe a case of metastatic breast carcinoma involving the uterus in a patient who had had a bilateral mastectomy due to invasive carcinoma NOS more than thirty years ago. Histological assessment of the hysteroscopy biopsy specimen including immunohistochemistry staining confirmed the breast carcinoma as the primary lesion, however it was classified as lobular carcinoma. The patient refused surgery or other invasive procedures, having complied nevertheless to follow up with clinical and ultrasound evaluation.

Conclusion

Metastatic breast disease to the feminine genital tract is more frequently due to lobular invasive carcinoma. We present a case of uterine metastization of invasive lobular carcinoma more than thirty years since the primary tumor, which was classified as invasive carcinoma NOS and confirmed by histological revision. It is of great importance to give the pathologist the correct information about the patient, namely of any oncologic background, so differential diagnosis can be made.

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乳腺癌子宫转移-病例报告
转移性疾病累及子宫是罕见的。通常是卵巢受累,原发肿瘤通常是乳房或胃肠道。病例报告:我们报告了一例转移性乳腺癌累及子宫的病例,该患者30多年前因浸润性肿瘤NOS行双侧乳房切除术。宫腔镜活检标本的组织学评估包括免疫组织化学染色证实乳腺癌为原发病变,但它被归类为小叶癌。患者拒绝手术或其他侵入性手术,但仍遵守临床和超声评估。结论乳腺转移到女性生殖道的疾病多由小叶浸润性癌引起。我们报告一例自原发肿瘤发生三十多年后的浸润性小叶癌发生子宫转移,经组织学检查证实为浸润性癌NOS。向病理学家提供关于患者的正确信息,即任何肿瘤背景的信息是非常重要的,因此可以做出鉴别诊断。
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