S. Subramanyam, Ramu Samineni, Sunil Kumar Kadiri, J. P. Yanadaiah, Phaneendranath Jonnalagedda, Krishna Veni Chikkula, Sampath A. Gouru
{"title":"Synthesis and In-vivo Bioactivity Studies of Some New Hydrazide Schiff Bases and Mannich Bases of Indole Derivatives","authors":"S. Subramanyam, Ramu Samineni, Sunil Kumar Kadiri, J. P. Yanadaiah, Phaneendranath Jonnalagedda, Krishna Veni Chikkula, Sampath A. Gouru","doi":"10.59467/ijhc.2023.33.289","DOIUrl":null,"url":null,"abstract":"The anti-inflammatory, analgesic, and antiulcer activities of eight new hydrazide Schiff bases and eight new Mannich bases of indole derivatives were investigated. 2-Methyl-1H-indole-3-carboxylate (III) on hydrazinolysis gave 2-methyl-1H-indole-3-carbohydrazide (IV), which on reaction with aldehydes gave corresponding hydrazide Schiff bases Va–Vh. The reaction of IV with formaldehyde, different aliphatic, aromatic, and heterocyclic amines afforded the Mannich bases of indole derivatives (VIa–VIe). The results of biological studies revealed that Schiff bases with 2,4-dichlorobenzaldehyde (Vh) and 2-chlorobenzaldehyde (Vb) were potent anti-inflammatory, analgesic, and antiulcer activities. Mannich bases (VIh and VIc) having -NO2 and -Cl groups in the paralocation of the heterocyclic nucleus displayed effective anti-inflammatory, analgesic, and antiulcer activities.","PeriodicalId":54993,"journal":{"name":"Indian Journal of Heterocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Heterocyclic Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.59467/ijhc.2023.33.289","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The anti-inflammatory, analgesic, and antiulcer activities of eight new hydrazide Schiff bases and eight new Mannich bases of indole derivatives were investigated. 2-Methyl-1H-indole-3-carboxylate (III) on hydrazinolysis gave 2-methyl-1H-indole-3-carbohydrazide (IV), which on reaction with aldehydes gave corresponding hydrazide Schiff bases Va–Vh. The reaction of IV with formaldehyde, different aliphatic, aromatic, and heterocyclic amines afforded the Mannich bases of indole derivatives (VIa–VIe). The results of biological studies revealed that Schiff bases with 2,4-dichlorobenzaldehyde (Vh) and 2-chlorobenzaldehyde (Vb) were potent anti-inflammatory, analgesic, and antiulcer activities. Mannich bases (VIh and VIc) having -NO2 and -Cl groups in the paralocation of the heterocyclic nucleus displayed effective anti-inflammatory, analgesic, and antiulcer activities.
期刊介绍：
Indian Journal of Heterocyclic Chemistry is exclusively devoted to research in the area of heterocyclic chemistry. The journal publishes invited review articles and original research papers pertaining to structure and synthesis, mechanism of reactions, spectral studies, biologically active compounds, bio-chemical studies, physicochemical work, phytochemistry etc.
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