Association between Anti-Sperm Antibody and Intra-cytoplasmic Sperm Injection Outcomes Among Male Infertility Patients

Haider Rafea Chiflawy Alkhafaji, Sahib Yahiya Hassan, Saaduldeen Gali Al-Esawi
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Abstract

Background: Infertility, a clinical and public concern, affects both social life and the health system. Sperm abnormalities which include (Oligozoospermia), (teratozoospermia) or abnormalities related to sperm motility are essential factors in male infertility. Anti-sperm antibodies (ASA) are the leading cause of immune infertility in men (autoimmune disease). Intra-cytoplasmic Sperm Injection (ICSI) is specially designed to manage severe cases of male-factor infertility. this study aimed to determine the effect of ASA on ICSI outcomes among Normospermia and (Oligozoospermia, Asthenozoospermia and Teratozoospermia). Material and methods: This is a cross-sectional study performed at Fertility Center, Najaf-Iraq between Jan to June 2023, it included 50 couples who suffered from a minimum of 12 months of primary fertility who had attended the Fertility Center. They were divided into four groups (Normospermia, Oligospermia, Teratozoospermia, and Asthenospermia) according to their seminal fluid analysis (SFA). Sperms were collected by ICSA, immobilized, and processed. The oocytes were collected, injected, and prepared for fertilization , after that fertilization took place. Finally, pregnancy was examined in each female partner. Results: there was no significant difference in the age of the four groups, there was no relationship between ASA and Sperm concentration, and there was no relationship between ASA and Normal Sperm Morphology, fertilization , & pregnancy rates, in addition to other ICSI outcomes, were similar among the four groups.in conclusion, pregnancy rates were higher in the normospermia group than the other three groups and ICSI overcomed the presence of ASA in the semen plasma.
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男性不育症患者抗精子抗体与胞浆内精子注射结果的关系
背景:不孕不育是一个临床和公众关注的问题,影响着社会生活和卫生系统。精子异常包括(少精症)、(畸形精症)或与精子运动相关的异常是男性不育的重要因素。抗精子抗体(ASA)是男性免疫性不育(自身免疫性疾病)的主要原因。胞浆内精子注射(ICSI)是专门设计用于管理男性因素不育的严重病例。本研究旨在确定ASA对正常精子症和(少精症、弱精症和畸形精子症)ICSI结果的影响。材料和方法:这是一项横断面研究,于2023年1月至6月在伊拉克纳杰夫的生育中心进行,其中包括50对在生育中心就诊的患有至少12个月原发性生育的夫妇。根据精液分析(SFA)将患者分为正常精子症、少精子症、畸形精子症和弱精子症4组。用ICSA收集精子,固定,处理。收集卵母细胞,注射,准备受精,受精发生后。最后,对每个女性伴侣的怀孕情况进行了检查。结果:四组患者年龄差异无统计学意义,ASA与精子浓度无相关性,ASA与正常精子形态、受精率、&无相关性;除其他ICSI结果外,四组的妊娠率相似。综上所述,正常精子症组的妊娠率高于其他三组,ICSI克服了精液血浆中ASA的存在。
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