Effect of Ximenia americana (Olacaceae) leaves on ovalbumin induced asthma in mice

Abstract

Ximenia americana commonly known as Sea Lemon is a plant of the Olacaceae family with anti-inflammatory, antioxidant and antiviral properties. Ximenia americana is used in traditional medicine for the treatment of diseases such as cancer, diabetes, asthma, etc. In this work, six groups of five mice were formed. The prevalence of clinical asthma is estimated at around 4.3% of the world's population, which is a real public health problem. Hence the aim of this work, which was to evaluate the effects of the aqueous extract of the leaves of X. americana on ovalbumin-induced asthma (OVA) in mice. The test animals received aqueous extract from Ximenia americana at doses 75 mg / kg, 150 mg / kg and 300 mg / kg. In order to measure the intensity of bronchial inflammation, the inflammatory cell rate has been evaluated. The results obtained after analysis of the different biochemical parameters show a significant decrease (p < 0.05) of the white blood cells in the positive lots, tests at 75 mg / kg, 150mg / kg, 300mg / kg compared to the negative light. In addition, a significant decrease in the average globular volume (MCV), blood platelets were recorded in these same animals (p < 0.01); (p < 0.001) respectively with respect to the negative group. The results also show that this allergen causes intense lipid peroxidation, as well as a significant reduction in the activity of different antioxidant systems (GSH, SOD and CAT). However, the pretreatment of Ximenia americana aqueous extract is effective, as to the significant reduction in the MDA rate (p < 0.001) and significant increase (p < 0.05) of the activity of CAT. The rebalance of the balance between oxidant and antioxidant during the plant administration, would probably be attributed to the antioxidant and anti-inflammatory capacity of the compounds contained in our extract.