Effect of a Self-Made Herbal Decoction Containing Angelica sinensis Combined with an Enhanced Recovery After Surgery Nursing Model on Anxiety, Depression, and Ovarian Function in Patients Undergoing Myomectomy

Abstract

Angelica sinensis (A. sinensis), a traditional Chinese medicine (TCM), can tonify the blood, promote circulation, and nourish the body. This study investigates the potential of A. sinensis extract in improving ovarian function at the molecular level and its combined effects with other natural medicinal herbs in patients undergoing myomectomy. The impact of A. sinensis extract was assessed using a rat model of premature ovarian insufficiency. The rats were divided into four groups: control group, model group, low-dose Angelica group, and high-dose Angelica group. Serum levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were determined, and the pathology of ovarian tissue was examined. The results revealed elevated expressions of E2, nuclear factor erythroid 2-related factor 2 (Nrf-2), and heme oxygenase-1 (HO-1) in the treated groups compared to the model group, along with decreased levels of LH, FSH, interleukin (IL)-4, IL-6, and tumor necrosis factor-α. In a clinical trial involving patients after myomectomy, the efficacy of a combination of TCM decoction containing A. sinensis and enhanced recovery after surgery nursing model was evaluated with anxiety, depression, and ovarian function as indicators. The observation group exhibited reduced levels of anxiety and depression, along with improved ovarian function compared to the control group. Moreover, it was observed that A. sinensis extract demonstrated the potential in enhancing ovarian function through molecular pathways, possibly involving Nrf-2/HO-1 signaling. These findings provide insights into novel therapeutic approaches for promoting ovarian health and emphasize the benefits of integrating traditional medicine with modern care strategies.