Mehdi Karimi, Kamran Roudini, Abolfazl Zendehdel, Fatemeh Toorang, S. Ebrahimpour-Koujan
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引用次数: 0
Abstract
Background: DNA oxidation is one of the essential destructive effects of reactive oxygen species (ROS) on the cell membrane macromolecules leading to the deformation of cellular DNA. The most abundant oxidative DNA product on which most studies have focused is re-oxidized DNA, 8 oxo-deoxyguanosine (8-oxodG). This deformation of cellular DNA is associated with various cancer initiation and progression. DNA damage can be a cancer marker including 8-oxodG, thymidine glycol, 8-oxoadenine, etc. DNA oxidation is affected by environmental and non-environmental factors. Age, diet, and metabolism are at the heart of this process. This review study summarizes the types of cancer-related DNA oxidation that serve as a cancer biomarker. Also, we will look at the factors influencing their formation.
背景：DNA 氧化是活性氧（ROS）对细胞膜大分子的重要破坏作用之一，会导致细胞 DNA 变形。大多数研究关注的最丰富的 DNA 氧化产物是再氧化 DNA，即 8-氧代脱氧鸟苷（8-oxodG）。细胞 DNA 的这种变形与各种癌症的发生和发展有关。DNA 损伤可作为癌症标志物，包括 8-oxodG、胸腺嘧啶二醇、8-oxoadenine 等。DNA 氧化受环境和非环境因素的影响。年龄、饮食和新陈代谢是这一过程的核心。本综述研究总结了作为癌症生物标志物的癌症相关 DNA 氧化类型。此外，我们还将探讨影响其形成的因素。
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