Influence and Mechanism of Traditional Chinese Medicine Intervention on Cognitive Dysfunction in Patients with Schizophrenia

Ningbo Yang, Hongxia Hu, Jie Li, Shaoli Shi, Yuling Wei, Yanhong Li, Wenwen Sun
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Abstract

This study investigates the impact and mechanisms of traditional Chinese medicine (TCM) intervention in patients with schizophrenia. In animal experiments, a total of 48 rats were randomly divided into four groups: control group (CG), model group (MG), Albizia flower flavonoid group (AFFG), and clozapine group (CLG). Each group consisted of 12 rats. After treatment, MK-801 was administered to the MG, AFFG, and CLG to establish schizophrenia rat models, while the CG received physiological saline. Cognitive abilities, hippocampal pathology, and protein expression were evaluated, and the expression levels of c-fos, cleaved Caspase-3, Bcl-2, and Bax were determined. In clinical trials, the study included 82 patients with schizophrenia treated at our hospital from February 2022 to February 2023. They were divided into the observation group (OG) and the experimental group (EG), with 41 cases in each group. The EG received aripiprazole and self-formulated TCM decoction, while the OG received aripiprazole. The PANSS scores and quality of life levels were compared. The results revealed impaired cognition, altered protein expression, and increased pathology in the MG compared to the CG. The AFFG and CLG exhibited enhanced cognition, improved protein expression, and reduced pathology when compared to the MG. Clinical findings demonstrated significantly lower PANSS scores and improved quality of life in the EG compared to the OG. In conclusion, Albizia flower flavonoids effectively modulated protein expression, ameliorated cognitive dysfunction, and reduced pathology. Additionally, the decoction decoction enhanced cognition and quality of life in patients with schizophrenia, suggesting promising clinical applications.
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中医干预对精神分裂症患者认知功能障碍的影响及机制
本研究探讨了中药干预对精神分裂症患者的影响和机制。在动物实验中,48只大鼠被随机分为四组:对照组(CG)、模型组(MG)、白芷花黄酮组(AFFG)和氯氮平组(CLG)。每组 12 只大鼠。治疗后,给 MG、AFFG 和 CLG 大鼠注射 MK-801 以建立精神分裂症大鼠模型,而给 CG 大鼠注射生理盐水。对认知能力、海马病理学和蛋白质表达进行了评估,并测定了 c-fos、裂解 Caspase-3、Bcl-2 和 Bax 的表达水平。在临床试验中,该研究纳入了82名2022年2月至2023年2月在我院接受治疗的精神分裂症患者。他们被分为观察组(OG)和实验组(EG),每组41例。实验组接受阿立哌唑和自拟中药煎剂治疗,观察组接受阿立哌唑治疗。两组患者的 PANSS 评分和生活质量水平进行了比较。结果显示,与 CG 相比,MG 的认知能力受损,蛋白质表达发生改变,病理变化增加。与MG相比,AFFG和CLG的认知能力增强,蛋白质表达改善,病理变化减少。临床研究结果表明,与 OG 相比,EG 的 PANSS 评分明显降低,生活质量得到改善。总之,白花蛇舌草黄酮能有效调节蛋白质表达,改善认知功能障碍,减少病理变化。此外,水煎剂还能提高精神分裂症患者的认知能力和生活质量,表明其临床应用前景广阔。
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来源期刊
Journal of Biobased Materials and Bioenergy
Journal of Biobased Materials and Bioenergy 工程技术-材料科学:生物材料
自引率
0.00%
发文量
60
审稿时长
6 months
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