{"title":"Brain Cortex Morphology in Rats After Cold Exposures","authors":"V. Lomako, O. Shylo, L. Pirozhenko","doi":"10.15407/cryo33.03.193","DOIUrl":null,"url":null,"abstract":"Morphological changes of the brain cortex sensorimotor area in 6-month-old rats were studied after short-term intermittent and long-term continuous cold exposures (STICE and LTCCE, respectively). Under these conditions, perivascular and pericellular edema, small solitary foci of necrosis with gliosis phenomena, \"porous\" neuropil (signs under STICE at –12°С and formation during LTCCE), dystrophically changed neurons, neurons with nuclei at different stages of necrobiosis were noted in the brain tissue against the background of native cyto- and myeloarchitectonics, Some of the microvessels had signs of inflammation and thrombi. A moderate constriction (after STICE at –12°С) and a dilatation (after STICE at 10°С) of microvessels were observed. According to the fractal analysis, a decrease in the fractal dimension of the brain cortex sections was found under both STICE at –12°С and LTCCE.","PeriodicalId":53457,"journal":{"name":"Problems of Cryobiology and Cryomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problems of Cryobiology and Cryomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15407/cryo33.03.193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Morphological changes of the brain cortex sensorimotor area in 6-month-old rats were studied after short-term intermittent and long-term continuous cold exposures (STICE and LTCCE, respectively). Under these conditions, perivascular and pericellular edema, small solitary foci of necrosis with gliosis phenomena, "porous" neuropil (signs under STICE at –12°С and formation during LTCCE), dystrophically changed neurons, neurons with nuclei at different stages of necrobiosis were noted in the brain tissue against the background of native cyto- and myeloarchitectonics, Some of the microvessels had signs of inflammation and thrombi. A moderate constriction (after STICE at –12°С) and a dilatation (after STICE at 10°С) of microvessels were observed. According to the fractal analysis, a decrease in the fractal dimension of the brain cortex sections was found under both STICE at –12°С and LTCCE.
期刊介绍：
The Journal publishes the reviews and original papers on cryobiological and cryomedical research, in particular the elucidation of mechanisms of injuries occurring in biological objects and caused by the influence of low and ultra low temperatures; natural resistance of biologicals to cold and their recovery post effect; the development of effective methods of cryoprotection and technology of storage of biological resources under hypothermic and ultra low temperatures, application of hypothermia, cryotherapy and cryopreserved biologicals for treating various pathologies; cell and tissue based therapies and other issues of low-temperature biology and medicine, as well as development of devices and equipment for low temperature biology and medicine. The journal covers all topics related to low temperature biology, medicine and engineering. These include but are not limited to: low temperature storage of biologicals (human, animal or plant cells, tissues, and organs), including preparation for storage, thawing/warming, cell and tissue culturing etc. response of biologicals to low temperature; cold adaptation of animals and plants; utilisation of low temperature in medicine; experimental and clinical transplantation, cell and tissue based therapies; developing of cryobiological and cryomedical devices; organisation and functioning of low temperature banks etc.
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