Development of Experimental Device for Inductive Heating of Magnetic Nanoparticles

Abstract

Abstract Inductive heating using magnetic nanoparticles (MNPs) is a critical process extensively investigated for cancer treatment. However, the high cost of commercially available equipment hinders its accessibility for many research groups. In response, this paper introduces a simple electronic circuit with low-cost components, making it easy to construct even for non-electronic experts. Operating within the 50 – 200 kHz range, the circuit employs a parallel inductor-capacitor configuration, providing a maximum induction magnetic field of 23.6 mT. Ltspice software simulations align well with oscilloscope measurements. Using commercial iron oxide nanoparticles (~16 nm) in water suspensions (1-10 mg/mL), the device exhibited a concentration-dependent reduction in Specific Absorption Rate (SAR) values, consistent with literature findings. Hyperthermia temperatures were achieved in a few minutes at 52.5 kHz and 23.6 mT in the highest concentration. At 81.9 kHz and 21.5 mT, a temperature of 93°C was achieved after 22 minutes at 10 mg/mL. Additionally, the device demonstrated stable and safe operation over a 100-minute period, as validated by an ice-melting experiment. These results highlight the device's efficacy for hyperthermia experiments in both biological and non-biological systems, particularly advantageous for larger nanoparticles in a blocked state. The proposed device holds significant potential for contributing to hyperthermia studies across diverse research groups. Future development will focus on frequency adjustment without reducing the alternating magnetic field amplitude and a thorough investigation of field homogeneity inside the coils.