Improvement of myocardial contractility with leadless endocardial single-lead atrial sensing ventricular pacing in patients with prolonged PQ interval.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI:10.2217/fca-2023-0112

Andrea Igoren Guaricci, Vincenzo Ezio Santobuono, Nicolò Soldato, Paolo Basile, Nicola Bozza, Maria Cristina Carella, Paola Siena, Cinzia Forleo, Gianluca Pontone, Marco Matteo Ciccone

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Abstract

Aim: Micra AV represents a leadless endocardial pacing system able to detect atrial contractions providing atrioventricular synchrony. A reduction of myocardial contractility may be detected in case of first-degree atrioventricular block (AVB). Materials & methods: In six patients with first-degree AVB (PQ interval ≥220 msec) was evaluated the left ventricle global longitudinal strain (LV GLS) by speckle tracking (ST) echocardiography during single-lead atrial sensing ventricular pacing (VDD) stimulation as compared with spontaneous rhythm (SR), 24-48 h after Micra AV implantation. Results: A statistically significant difference between the two modalities was observed (LV GLS during SR: -14.7% [interquartile range (IQR) 5.5], LV GLS during VDD pacing: -16.1% [IQR 5.2]; p value = 0.041). Conclusion: Our preliminary results suggest an improvement of myocardial contractility with VDD pacing as compared with SR.

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通过无导联心内膜单导联心房传感心室起搏改善 PQ 间期延长患者的心肌收缩力

目的：Micra AV 是一种无导联心内膜起搏系统，能够检测心房收缩，实现房室同步。在出现一级房室传导阻滞（AVB）时，可检测到心肌收缩力的减弱。材料和方法：对六名一级房室传导阻滞（PQ 间期≥220 毫秒）患者在 Micra AV 植入 24-48 小时后进行单导联心房传感心室起搏（VDD）刺激时，通过斑点追踪（ST）超声心动图评估左心室整体纵向应变（LV GLS），并与自发节律（SR）进行比较。结果：观察到两种模式之间存在统计学意义上的显著差异（SR 期间的左心室 GLS：-14.7% [四分位数间距 (IQR) 5.5]，VDD 起搏期间的左心室 GLS：-16.1% [IQR 5.2]；P 值 = 0.041）。结论我们的初步结果表明，与 SR 相比，VDD 起搏可改善心肌收缩力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.