Impact of fine particulate matter on latent tuberculosis infection and active tuberculosis in older adults: a population-based multicentre cohort study.

IF 8.4 2区 医学 Q1 IMMUNOLOGY Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-01-29 DOI:10.1080/22221751.2024.2302852
Tonglei Guo, Sifan Tian, Henan Xin, Jiang Du, Xuefang Cao, Boxuan Feng, Yijun He, Yongpeng He, Dakuan Wang, Bin Zhang, Zisen Liu, Jiaoxia Yan, Lingyu Shen, Yuanzhi Di, Yanxiao Chen, Qi Jin, Shouguo Pan, Marianthi-Anna Kioumourtzoglou, Lei Gao, Xu Gao
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Abstract

Evidence showed that air pollution was associated with an increased risk of tuberculosis (TB). This study aimed to study the impact of long-term exposure to ambient particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) on the acquisition of LTBI and on the risk of subsequent active disease development among rural older adults from a multicentre cohort, which have not yet been investigated to date. A total of 4790 older adults were included in a population-based, multicentre, prospective cohort study (LATENTTB-NSTM) from 2013 to 2018. The level of long-term exposure to PM2.5 for each participant was assessed by aggregating satellite-based estimates. Logistic regression and time-varying Cox proportional hazards models with province-level random intercepts were employed to assess associations of long-term exposures to PM2.5 with the risk of LTBI and subsequent development of active TB, respectively. Out of 4790 participants, 3284 were LTBI-free at baseline, among whom 2806 completed the one-year follow-up and 127 developed newly identified LTBI. No significant associations were identified between PM2.5 and the risk of LTBI. And among 1506 participants with LTBI at baseline, 30 active TB cases were recorded during the 5-year follow-up. Particularly, an increment of 5 μg/m3 in 2-year moving averaged PM2.5 was associated with a 50.6% increased risk of active TB (HR = 1.506, 95% CI: 1.161-1.955). Long-term air pollution might be a neglected risk factor for active TB development from LTBI, especially for those living in developing or less-developed areas where the air quality is poor.

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细颗粒物对老年人肺结核潜伏感染和活动性肺结核的影响:基于人群的多中心队列研究。
摘要有证据表明,空气污染与结核病(TB)风险的增加有关。本研究旨在研究长期暴露于空气动力学直径小于 2.5 μm 的环境颗粒物(PM2.5)对农村老年人获得迟发性肺结核和随后发展为活动性疾病的风险的影响。一项基于人群的多中心前瞻性队列研究(LATENTTB-NSTM)共纳入了4790名老年人,研究时间为2013年至2018年。每位参与者长期暴露于PM2.5的水平是通过汇总卫星估算值来评估的。采用逻辑回归和时变考克斯比例危险模型(带有省一级随机截距)分别评估长期暴露于PM2.5与LTBI风险和随后发展为活动性肺结核的相关性。在4790名参与者中,有3284人在基线时没有LTBI,其中2806人完成了为期一年的随访,127人新发现了LTBI。在PM2.5与LTBI风险之间没有发现明显的关联。在1506名基线时患有LTBI的参与者中,有30人在5年的随访中发现了活动性肺结核病例。特别是,PM2.5的2年移动平均值每增加5微克/立方米,活动性肺结核的风险就会增加50.6%(HR = 1.506,95% CI:1.161-1.955)。长期的空气污染可能是导致长期肺结核发展为活动性肺结核的一个被忽视的风险因素,尤其是对于那些生活在空气质量较差的发展中国家或欠发达地区的人来说。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Emerging Microbes & Infections
Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY
CiteScore
26.20
自引率
2.30%
发文量
276
审稿时长
20 weeks
期刊介绍: Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.
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