Modern technology advances of Pseudomonas aeruginosa based biosensor approach

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology Biosensors and Bioelectronics: X Pub Date : 2024-01-22 DOI:10.1016/j.biosx.2024.100441

Dhanendiren Narayanasamy , Safura Taufik , Ahmad Farid Mohd Azmi , Siti Aminah Mohd Nor , Jahwarhar Izuan Abdul Rashid

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Abstract

The threat posed by microbial infections to human health remains very significant, particularly in considering the increasing mechanisms of antibiotic resistance. Pseudomonas aeruginosa is known for its antibiotic resistance and is linked to serious conditions like ventilator-associated pneumonia and cystic fibrosis. Rapid infection elimination relies on identifying harmful bacteria and preventing colonization. Due to the redox-active nature of P. aeruginosa biomarkers metabolites, several electrochemical sensing approaches are being evaluated as diagnostic platforms for the rapid and precise detection of P. aeruginosa with high sensitivity. These sensors must be developed and modified to achieve optimal selectivity, sensitivity, and biocompatibility, enabling dynamic, real-time metabolite detection. This minireview highlights recent advancements in electrochemical and optical biosensors for detecting P. aeruginosa biomarkers, particularly pyocyanin. It highlighted design, analytical performance, biological recognition elements, and personalized wearable electrochemical sensor devices. It concludes with the future suggestions of sensor concepts for clinical diagnostics, environmental monitoring, and food safety.

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基于铜绿假单胞菌生物传感器方法的现代技术进展

微生物感染对人类健康的威胁仍然非常大，特别是考虑到抗生素耐药性机制日益增强。众所周知，铜绿假单胞菌具有抗生素耐药性，与呼吸机相关性肺炎和囊性纤维化等严重疾病有关。快速消除感染依赖于识别有害细菌和防止定植。由于铜绿假单胞菌生物标志物代谢物具有氧化还原活性，目前正在对几种电化学传感方法进行评估，将其作为快速、精确、高灵敏度检测铜绿假单胞菌的诊断平台。这些传感器必须经过开发和改良，以达到最佳的选择性、灵敏度和生物兼容性，从而实现动态、实时的代谢物检测。本微型综述重点介绍了用于检测铜绿假单胞菌生物标记物（尤其是焦花青素）的电化学和光学生物传感器的最新进展。它重点介绍了设计、分析性能、生物识别元素和个性化可穿戴电化学传感器装置。最后，还就临床诊断、环境监测和食品安全方面的传感器概念提出了未来建议。

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来源期刊

Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

166

审稿时长

54 days

期刊介绍： Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.