Redefining Wound Healing Using Near-Infrared Spectroscopy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-01 Epub Date: 2024-03-12 DOI:10.1097/ASW.0000000000000115

Charles Andersen, Homer-Christian J Reiter, Valerie L Marmolejo

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Abstract

Objective: No standard definition for a completely healed wound currently exists; it is recommended that providers use a reliable wound assessment tool to determine healing. The objective of this feasibility study was to determine if a point-of-care, noncontact, near-infrared (NIR) imaging device could provide an objective measure of wound resolution and guide clinical decision-making for the optimal time to transition from protective wound dressings and gradual return to full activity.

Methods: In this single-center feasibility study, adult patients 18 years and older with a lower extremity wound of any size and etiology were seen weekly for wound assessment and standard-of-care treatment. The researchers performed serial imaging with a point-of-care, noncontact, NIR imaging device (Snapshot NIR ; Kent Imaging Inc) to assess the wound and surrounding skin and evaluated the difference in time to 100% reepithelialization on visual inspection and homogeneous tissue oxygen saturation levels at the wound site and surrounding closed skin envelope.

Results: An average time difference of 13.5 ± 10 days (median, 12 days; range, 0-35 days) was observed between 100% reepithelialization on visual wound inspection and imaging assessment. Further, NIR imaging could determine when a patient was at risk for recurrent wound breakdown.

Conclusions: The addition of point-of-care, noncontact, NIR imaging may help guide clinical decision-making for the optimal time to transition from protective wound dressings with gradual return to full activity and minimize wound recurrence.

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利用近红外光谱重新定义伤口愈合。

目标：目前还没有关于伤口完全愈合的标准定义；建议医疗服务提供者使用可靠的伤口评估工具来确定伤口愈合情况。这项可行性研究的目的是确定一种护理点、非接触式、近红外（NIR）成像设备能否提供伤口愈合的客观测量方法，并指导临床决策，以确定从保护性伤口敷料过渡到逐渐恢复全面活动的最佳时间：在这项单中心可行性研究中，18 岁及以上、下肢伤口大小和病因不限的成年患者每周接受一次伤口评估和标准护理治疗。研究人员使用护理点非接触式近红外成像设备（SnapshotNIR；Kent Imaging Inc）对伤口和周围皮肤进行连续成像评估，并评估目测伤口100%再上皮化的时间差异以及伤口部位和周围闭合皮肤包膜的均匀组织氧饱和度水平：结果：目测伤口 100%再上皮与成像评估之间的平均时间差为 13.5 ± 10 天（中位数，12 天；范围，0-35 天）。近红外成像还能进一步确定患者何时有伤口复发的风险：结论：增加护理点非接触式近红外成像技术有助于指导临床决策，确定从保护性伤口敷料过渡到逐渐恢复全面活动的最佳时间，并最大限度地减少伤口复发。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.