V. I. Kapelko, V. L. Lakomkin, A. A. Abramov, A. V. Prosvirnin
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引用次数: 0
Abstract
The major property of the myocardium that determines left
ventricular (LV) filling is its distensibility. The simplest measure
for its assessment is the LV end-diastolic pressure–volume ratio,
although it can vary within a wide range and is highly dependent
on inflow and resistance boundary conditions, making distensibility
difficult to assess. Here, we consider six calculated indices of
LV diastolic stiffness, most of which are based on Hooke’s law,
comparing their stability, variation, and correlation coefficients
with different hemodynamic parameters. The diastolic stiffness index
No. 4 proved to be the only measure that takes into account an increase
in LV stiffness over diastole. It shows a weak dependence on LV ejection
fraction, heart rate, and other parameters of LV hemodynamics, and
hence can be used to assess LV diastolic distensibility in various
cardiac pathologies.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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