Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-03-25 DOI:10.1007/s10856-024-06786-y
Jing Wang, Yisheng Yin, Xiang Ren, Shaogang Wang, Yunpeng Zhu
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Abstract

The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8+ T cells and NKp46+ NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors.

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负载吉西他滨和顺铂的电纺纳米纤维垫通过改善肿瘤免疫微环境抑制膀胱肿瘤的生长。
与手术切缘阳性相关的令人困惑的问题以及与全身化疗相关的相当大的负面影响给临床医生带来了持续的挑战,尤其是在膀胱癌治疗方面。目前的研究介绍了利用电纺丝技术生产出负载吉西他滨(GEM)和顺铂(CDDP)的纳米复合材料。体外和体内研究证明,这种纳米复合材料能有效抑制肿瘤的发展,同时减少化疗药物在肝脏和肾脏组织中的积聚。从机理上讲,GEM和CDDP负载的电纺纳米复合材料能有效消除肿瘤组织中的髓源性抑制细胞(MDSCs),并招募CD8+ T细胞和NKp46+ NK细胞杀伤肿瘤细胞,还能有效抑制肿瘤微血管的形成。我们对通过GEM和CDDP负载的电纺纳米复合材料局部给药化疗对肿瘤微环境影响的研究,将为应对肿瘤提供新的见解。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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