SmartLipids: Ushering in a New Era of Lipid Nanoparticles for Drug Delivery

Abstract

In the realm of drug delivery, lipid nanoparticles have emerged as versatile carriers, offering enhanced encapsulation, protection, and targeted delivery of therapeutic agents. Among these innovative systems, SmartLipids stands out as a groundbreaking advancement, representing the latest generation of lipid nanoparticles. Characterized by their unique "chaotic" and disordered particle matrix structure, SmartLipids exhibit remarkable properties that set them apart from conventional drug delivery systems. This comprehensive review delves into the intricate world of SmartLipids, unraveling their distinctive features and exploring their immense potential in the field of drug delivery. It meticulously outlines their production methods, shedding light on the solvent-free, highpressure homogenization technique that ensures biocompatibility and safety. The review meticulously examines the physicochemical characterization of SmartLipids, providing insights into their particle size, morphology, and encapsulation efficiency. It further delves into their in vitro and in vivo performance, highlighting their ability to enhance drug solubility, permeability, and bioavailability. The study collectively underscores the versatility and customizable nature of SmartLipids, emphasizing their suitability for a wide range of drug delivery applications. From encapsulating hydrophilic, lipophilic, and amphiphilic compounds to tailoring specific release profiles, SmartLipids offer a remarkable degree of flexibility in drug delivery strategies.