A. D. Shevlyakov, N. P. Ilyin, D. S. Galstyan, A. N. Ikrin, T. O. Kolesnikova, K. V. Apukhtin, M. M. Kotova, V. S. Nikitin, T. G. Amstislavskaya, A. V. Kalueff
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引用次数: 0
Abstract
Traumatic brain injury (TBI) involves multiple types of physical
brain lesions. TBI is a highly heterogeneous clinical condition
whose symptoms include cognitive, motor and emotional deficits,
as well as neurodegeneration and neuroinflammation. TBI modeling
in animals plays a key role in studying its pathogenetic mechanisms
and temporal dynamics, as well as developing new drugs for its treatment. Recently,
the use of the zebrafish Danio rerio as
a model organism has aroused the growing interest of translational
neurobiology. Zebrafish are now the second most demanded laboratory
animal species in biomedicine, after mice. Here, we discuss the
prospects of using this teleost fish as a model of TBI, as well
as new research trends in this area. We also emphasize the importance
of zebrafish as a highly translational model for studying the molecular
mechanisms and neurological disorders in TBI, as well as screening
for potential therapeutic agents.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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