"Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles"

Karthik K Karunakar , Binoy Varghese Cheriyan , Krithikeshvaran R , Gnanisha M , Abinavi B
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Abstract

Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs, large surface area, and unique physicochemical properties contribute to cell lysis and increased permeability of cell membranes used in the field of biomedicine. Functional precursors integrate with phytochemicals to create distinctive therapeutic properties and the stability of the nanoparticles can be enhanced by Surface coatings and encapsulation methods, The current study explores the various synthesis methods and characterization techniques of silver nanoparticles (AgNPs) and highlights their intrinsic activity in therapeutic applications, Anti-cancer activity noted at a concentration range of 5–50 μg/ml and angiogenesis is mitigated at a dosage range of 10–50 μg/ml, Diabetes is controlled within the same concentration. Wound healing is improved at concentrations of 10–50 μg/ml and with a typical range of 10–08 μg/ml for bacteria with antimicrobial capabilities. Advancement of silver nanoparticles with a focus on the future use of AgNPs-coated wound dressings and medical devices to decrease the risk of infection. Chemotherapeutic drugs can be administered by AgNPs, which reduces adverse effects and an improvement in treatment outcomes. AgNPs have been found to improve cell proliferation and differentiation, making them beneficial for tissue engineering and regenerative medicine. Our study highlights emerging patterns and developments in the field of medicine, inferring potential future paths.

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"纳米医学的治疗进展:银纳米粒子的多方面作用"
纳米技术具有增强生物活性、降低毒性、靶向特异性和持续释放等优点,而且纳米粒子可以穿透细胞膜。银纳米粒子(AgNPs)体积小、表面积大,具有独特的物理化学特性,有助于细胞裂解和提高细胞膜的渗透性,可用于生物医学领域。目前的研究探讨了银纳米粒子(AgNPs)的各种合成方法和表征技术,并强调了它们在治疗应用中的内在活性,在 5-50 μg/ml 的浓度范围内具有抗癌活性,在 10-50 μg/ml 的剂量范围内可减轻血管生成,在相同浓度范围内可控制糖尿病。在 10-50 μg/ml 的浓度范围内可改善伤口愈合,在 10-08 μg/ml 的典型浓度范围内对细菌具有抗菌能力。推动银纳米粒子的发展,重点是未来使用AgNPs涂层的伤口敷料和医疗器械来降低感染风险。化疗药物可通过 AgNPs 给药,从而减少不良反应,改善治疗效果。研究还发现,AgNPs 可促进细胞增殖和分化,从而有利于组织工程和再生医学。我们的研究强调了医学领域的新兴模式和发展,并推断出未来的潜在发展方向。
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