Research on the Influencing Factors of Peristalsis Amplitude Based on an in Vitro Bionic Rat Stomach Model

Abstract

The In Vitro Bionic Digestion Model (IVBDM) are used to simulate the digestion process of food or pharmaceuticals in corresponding digestion tracts for obtaining the digestion data, which are expected to replace in vivo experiments with animals in the early stages of functional food or drug development, and thus have broad applications prospects. However, little is known so far about how the factors including the Young’s modulus of the model, the level, location and direction of the applied load, affect the peristalsis amplitude of the IVBDM. Based on an In Vitro Bionic Rat Stomach Model (IVBRSM), simulation and experimental analysis were conducted to examine the factors effecting the peristalsis amplitude of the IVBRSM. It is shown that Young’s modulus of the model significantly affects the peristalsis amplitude, with lower Young’s modulus resulting in larger amplitude. Load level, location, and direction also influence the peristalsis amplitude. Additionally, IVBRSM size and wall thickness play a role, with larger models requiring higher load levels or lower Young’s modulus for the same peristalsis amplitude. Simulation data correlate well with experimental results. These findings contribute to the understanding of the peristalsis state of IVBRSM under different conditions and can guide the design and fabrication of such in vitro bionic digestion models.