Deciphering Parkinson’s Disease through Eye Movements: A Promising Tool for Early Diagnosis in the Face of Cognitive Impairment

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Clinical Practice Pub Date : 2024-06-21 DOI:10.1155/2024/5579238
Xianglian Liao, Jian Yao, Hongyin Tang, Yilan Xing, Xin Zhao, Daao Nie, Ping Luan, Guihua Li
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Abstract

Cognitive dysfunction is the most common and important nonmotor symptom in Parkinson’s disease (PD) and can occur at any stage. However, there is still a lack of effective biomarkers to evaluate the decline in cognitive function and predict the progression of the disease, especially in the early stage. At present, the cognitive scale is widely used to evaluate the cognitive function of patients with PD, but its sensitivity and accuracy are relatively limited, especially in the early identification of mild cognitive impairment. Eye movement tracking is an advanced neurophysiological measurement method that serves as a powerful means to study the relationship between behavior and neural mechanisms. In recent years, eye movement tracking has been found to provide a nonverbal and less cognitive method to measure the disease progress of patients with cognitive impairment. Moreover, there is a good correlation between eye movement tracking and the traditional cognitive assessment scale, indicating that eye movement tracking can be used to evaluate and monitor the cognitive status, disease severity, and disease progression of patients with PD. Compared to the traditional cognitive scale, the eye movement detected by the instrument has better objectivity and repeatability. Existing studies have found that executive dysfunction is one of the most important manifestations of cognitive dysfunction in patients with PD and is related to an increase in the error rate of the saccade, an increase in the disinhibition of the delayed saccade task, and a prolongation of the saccade reaction time. This suggests that eye movement measurement plays an important role in the early diagnosis, progression, and differential diagnosis of PD and may even help to predict the disease progression of patients with PD and cognitive impairment. In this article, we review the correlation between cognitive impairment and eye movement disorder in patients with PD.

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通过眼动解密帕金森病:认知障碍早期诊断的有效工具
认知功能障碍是帕金森病(PD)最常见、最重要的非运动症状,可发生在任何阶段。然而,目前仍缺乏有效的生物标志物来评估认知功能的下降并预测疾病的进展,尤其是在早期阶段。目前,认知量表被广泛用于评估帕金森病患者的认知功能,但其灵敏度和准确性相对有限,尤其是在早期识别轻度认知障碍方面。眼动跟踪是一种先进的神经生理学测量方法,是研究行为与神经机制关系的有力手段。近年来,人们发现眼动跟踪是一种非语言且认知程度较低的测量认知障碍患者疾病进展的方法。此外,眼动追踪与传统认知评估量表之间存在良好的相关性,表明眼动追踪可用于评估和监测帕金森病患者的认知状态、疾病严重程度和疾病进展。与传统认知量表相比,该仪器检测到的眼动具有更好的客观性和可重复性。现有研究发现,执行功能障碍是帕金森病患者认知功能障碍的重要表现之一,与囊回错误率增加、延迟囊回任务抑制增加和囊回反应时间延长有关。这表明眼动测量在帕金森病的早期诊断、进展和鉴别诊断中起着重要作用,甚至有助于预测帕金森病和认知障碍患者的疾病进展。本文回顾了认知障碍与帕金森病患者眼球运动障碍之间的相关性。
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来源期刊
CiteScore
5.30
自引率
0.00%
发文量
274
审稿时长
3-8 weeks
期刊介绍: IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
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