Effect of Iron Accumulation on Bone Mineral Density in Patients Diagnosed With Transfusion-Dependent Thalassemia

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Clinical Practice Pub Date : 2025-02-22 DOI:10.1155/ijcp/5411059

Cem Selim, Rafiye Çiftçiler, Ayşe Hilal Eroğlu Küçükdiler, Fatma Keklik Karadağ, Nur Soyer

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Abstract

Introduction: Transfusion-dependent thalassemia (TDT) is most commonly caused by defects in beta globin chain production. Iron overload, hypogonadism, vitamin D deficiency, adverse effects of desferrioxamine treatment, and delayed puberty due to loss of bone mass are the main complications of TDT. In the present study, we aimed to investigate bone complications and precursor markers in TDT patients.

Materials and Methods: Our retrospective study included 93 patients, aged between 18 and 45, who were followed up in a tertiary care institution and did not have any disease other than TDT. The patients’ BMD values and biochemical parameters were compared.

Results: Osteoporosis was observed in 33 of 93 patients, and the mean transferrin saturation of patients with osteoporosis was 60%, and the mean transferrin saturation of patients without osteoporosis was 42%. Patients with osteoporosis had transferrin saturation that was observed to be considerably higher than that of the group without osteoporosis (p = 0.006), with an average of 60%.

Conclusion: Our investigation has demonstrated that in patients with TDT, elevated transferrin saturation may be a sign of osteoporosis.

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铁积累对输血依赖型地中海贫血患者骨密度的影响

输血依赖性地中海贫血（TDT）最常见的原因是β -珠蛋白链产生缺陷。铁超载、性腺功能减退、维生素D缺乏、去铁胺治疗的不良反应以及骨量丢失导致的青春期延迟是TDT的主要并发症。在本研究中，我们旨在研究TDT患者的骨并发症和前体标志物。材料和方法：我们的回顾性研究纳入了93例患者，年龄在18至45岁之间，在三级医疗机构随访，除TDT外无其他疾病。比较两组患者的骨密度和生化指标。结果：93例患者中有33例出现骨质疏松，骨质疏松患者的平均转铁蛋白饱和度为60%，非骨质疏松患者的平均转铁蛋白饱和度为42%。骨质疏松患者的转铁蛋白饱和度明显高于非骨质疏松组（p = 0.006），平均为60%。结论：我们的研究表明，在TDT患者中，转铁蛋白饱和度升高可能是骨质疏松症的征兆。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.