Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-06-19 DOI:10.1016/j.clinph.2024.06.006

Robin E. Heemels , Sian Ademi , Melina Hehl

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Abstract

Objective

Investigating the optimal interstimulus interval (ISI) and the 24-hour test–retest reliability for intrahemispheric dorsal premotor cortex (PMd) – primary motor cortex (M1) connectivity using dual-site transcranial magnetic stimulation (dsTMS).

Methods

In 21 right-handed adults, left intrahemispheric PMd–M1 connectivity has been investigated with a stacked-coil dsTMS setup (conditioning stimulus: 75% of resting motor threshold; test stimulus: eliciting MEPs of 1–1.5 mV) at ISIs of 3, 5–8, and 10 ms. Additionally, M1–M1 short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were investigated to assess comparability to standard paired-pulse setups.

Results

Conditioning PMd led to significant inhibition of M1 output at ISIs of 3 and 5 ms, whereas 10 ms resulted in facilitation (all, p < 0.001), with a fair test–retest reliability for 3 (ICC: 0.47) and 6 ms (ICC: 0.44) ISIs. Replication of SICI (p < 0.001) and ICF (p = 0.017) was successful, with excellent test–retest reliability for SICI (ICC: 0.81).

Conclusion

This dsTMS setup can probe the inhibitory and facilitatory PMd–M1 connections, as well as reliably replicate SICI and ICF paradigms.

Significance

The stacked-coil dsTMS setup for investigating intrahemispheric PMd–M1 connectivity offers promising possibilities to better understand motor control.

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半球内背侧前运动皮层和初级运动皮层双部位 TMS 连接测量的测试-再测可靠性。

研究目的使用双部位经颅磁刺激（dsTMS）研究半球内背侧前运动皮层（PMd）-初级运动皮层（M1）连接的最佳刺激间隔（ISI）和24小时测试-重复可靠性：方法：在21名惯用右手的成年人中，使用堆叠线圈dsTMS设置（条件刺激：静息运动阈值的75%；测试刺激：引起1-1.5 mV的MEPs），在3、5-8和10 ms的ISIs下，对左侧半球内PMd-M1连接性进行了研究。此外，还研究了M1-M1短间隔皮层内抑制（SICI）和皮层内促进（ICF），以评估与标准配对脉冲设置的可比性：结果：在 ISI 为 3 和 5 毫秒时，条件 PMd 导致 M1 输出的显著抑制，而在 10 毫秒时则导致促进（均为 p 结论）：这种 dsTMS 设置可探测 PMd-M1 的抑制性和促进性连接，并可靠地复制 SICI 和 ICF 范式：意义：用于研究大脑半球内 PMd-M1 连接的堆叠线圈 dsTMS 装置为更好地了解运动控制提供了可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.