Auditory cortical and brainstem response dynamics in quiet and noise amongst unilaterally deaf adults with and without tinnitus

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI:10.1016/j.clinph.2025.02.260

MinChul Park , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin

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Abstract

Objective

Cortical auditory evoked potentials (CAEPs) and Auditory Brainstem Responses (ABRs) elicited by sounds in quiet and in noise were compared between unilaterally deaf adults with and without associated tinnitus (UD+T and UD-T). CAEP amplitudes were hypothesised to primarily vary with absolute stimulus levels in UD+T listeners rather than signal-to-noise ratio (SNR), whereas ABR amplitudes would reflect both level and SNR regardless of tinnitus status.

Methods

Responses were recorded at 60 and 45 dB nHL with white noise set to give 0 and +10 dB SNR. Participants were 8 UD-T, 13 UD+T listeners, and 13 binaurally hearing controls.

Results

The UD-T group CAEP amplitudes showed an additive effect of stimulus level (p = 0.025) and SNR (p = 0.002) while UD+T and control listeners showed only the effect of SNR (p = 0.004). ABR amplitudes reflected the additive effects of level and SNR in all groups.

Conclusions

The primary determinant of CAEP amplitudes to signals in noise is SNR not stimulus level. This effect was not apparent in UD-T listeners, whose amplitudes were determined by both level and SNR, similarly to the brainstem potentials.

Significance

The findings suggest altered processing of neural noise in unilaterally deaf adult listeners without tinnitus.

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有或无耳鸣的单侧聋成人在安静和噪音环境下的听觉皮层和脑干反应动力学

目的比较成人单侧耳聋伴和不伴耳鸣（UD+T和UD-T）在安静和噪声环境下的皮层听觉诱发电位（CAEPs）和听觉脑干反应（ABRs）。假设CAEP振幅主要随UD+T听者的绝对刺激水平而变化，而不是信噪比（SNR），而ABR振幅则反映水平和信噪比，无论耳鸣状态如何。方法记录60和45 dB nHL下的反应，白噪声设置为0和+10 dB信噪比。参与者为8名UD-T听者，13名UD+T听者和13名双耳听力对照者。结果UD-T组CAEP振幅存在刺激水平（p = 0.025）和信噪比（p = 0.002）的叠加效应，UD+T组和对照组仅存在信噪比的叠加效应（p = 0.004）。ABR波幅反映了各组水平和信噪比的叠加效应。结论噪声条件下CAEP振幅的主要决定因素是信噪比而非刺激水平。这种效应在UD-T听者中并不明显，其振幅由水平和信噪比决定，类似于脑干电位。意义：本研究提示成人单侧耳聋无耳鸣患者神经噪声加工发生改变。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.