Histopathologic Features of Mucosal Head and Neck Cancer Cachexia.

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI:10.1155/2024/5339292
Alexander J Jones, Leah J Novinger, Andrea Bonetto, Kyle P Davis, Marelle M Giuliano, Avinash V Mantravadi, Michael W Sim, Michael G Moore, Jessica A Yesensky
{"title":"Histopathologic Features of Mucosal Head and Neck Cancer Cachexia.","authors":"Alexander J Jones, Leah J Novinger, Andrea Bonetto, Kyle P Davis, Marelle M Giuliano, Avinash V Mantravadi, Michael W Sim, Michael G Moore, Jessica A Yesensky","doi":"10.1155/2024/5339292","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Determine the histopathologic features that correlate with head and neck cancer (HNC) cachexia.</p><p><strong>Methods: </strong>A single-institution, retrospective study was performed on adults with HPV-negative, mucosal squamous cell carcinoma of the aerodigestive tract undergoing resection and free flap reconstruction from 2014 to 2019. Patients with distant metastases were excluded. Demographics, comorbidities, preoperative nutrition, and surgical pathology reports were collected. Comparisons of histopathologic features and cachexia severity were made.</p><p><strong>Results: </strong>The study included 222 predominantly male (64.9%) patients aged 61.3 ± 11.8 years. Cachexia was identified in 57.2% patients, and 18.5% were severe (≥15% weight loss). No differences in demographics were identified between the groups. Compared to control, patients with severe cachexia had lower serum hemoglobin (<i>p</i>=0.048) and albumin (<i>p</i> < 0.001), larger tumor diameter (<i>p</i> < 0.001), greater depth of invasion (<i>p</i> < 0.001), and elevated proportions of pT4 disease (<i>p</i> < 0.001), pN2-N3 disease (<i>p</i>=0.001), lymphovascular invasion (<i>p</i>=0.009), and extranodal extension (<i>p</i>=0.014). Multivariate logistic regression identified tumor size (OR [95% CI] = 1.36 [1.08-1.73]), oral cavity tumor (OR [95% CI] = 0.30 [0.11-0.84]), and nodal burden (OR [95% CI] = 1.16 [0.98-1.38]) as significant histopathologic contributors of cancer cachexia.</p><p><strong>Conclusions: </strong>Larger, more invasive tumors with nodal metastases and aggressive histologic features are associated with greater cachexia severity in mucosal HNC.</p>","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223910/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2024/5339292","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Determine the histopathologic features that correlate with head and neck cancer (HNC) cachexia.

Methods: A single-institution, retrospective study was performed on adults with HPV-negative, mucosal squamous cell carcinoma of the aerodigestive tract undergoing resection and free flap reconstruction from 2014 to 2019. Patients with distant metastases were excluded. Demographics, comorbidities, preoperative nutrition, and surgical pathology reports were collected. Comparisons of histopathologic features and cachexia severity were made.

Results: The study included 222 predominantly male (64.9%) patients aged 61.3 ± 11.8 years. Cachexia was identified in 57.2% patients, and 18.5% were severe (≥15% weight loss). No differences in demographics were identified between the groups. Compared to control, patients with severe cachexia had lower serum hemoglobin (p=0.048) and albumin (p < 0.001), larger tumor diameter (p < 0.001), greater depth of invasion (p < 0.001), and elevated proportions of pT4 disease (p < 0.001), pN2-N3 disease (p=0.001), lymphovascular invasion (p=0.009), and extranodal extension (p=0.014). Multivariate logistic regression identified tumor size (OR [95% CI] = 1.36 [1.08-1.73]), oral cavity tumor (OR [95% CI] = 0.30 [0.11-0.84]), and nodal burden (OR [95% CI] = 1.16 [0.98-1.38]) as significant histopathologic contributors of cancer cachexia.

Conclusions: Larger, more invasive tumors with nodal metastases and aggressive histologic features are associated with greater cachexia severity in mucosal HNC.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
头颈部黏膜癌 "头痛症 "的组织病理学特征
目的:确定与头颈癌(HNC)恶病质相关的组织病理学特征:确定与头颈癌(HNC)恶病质相关的组织病理学特征:2014年至2019年期间,对接受切除术和游离皮瓣重建术的HPV阴性成人消化道粘膜鳞状细胞癌患者进行了一项单一机构的回顾性研究。排除了有远处转移的患者。研究人员收集了患者的人口统计学资料、合并症、术前营养状况和手术病理报告。对组织病理学特征和恶病质严重程度进行了比较:研究共纳入 222 名男性患者(64.9%),年龄为 61.3 ± 11.8 岁。57.2%的患者出现恶病质,18.5%为重度恶病质(体重下降≥15%)。两组患者的人口统计学特征无差异。与对照组相比,重度恶病质患者的血清血红蛋白(p=0.048)和白蛋白(p<0.001)更低,肿瘤直径更大(p<0.001),浸润深度更深(p<0.001),pT4病变(p<0.001)、pN2-N3病变(p=0.001)、淋巴管浸润(p=0.009)和结节外扩展(p=0.014)的比例更高。多变量逻辑回归确定肿瘤大小(OR [95% CI] = 1.36 [1.08-1.73])、口腔肿瘤(OR [95% CI] = 0.30 [0.11-0.84])和结节负荷(OR [95% CI] = 1.16 [0.98-1.38])是导致癌症恶病质的重要组织病理学因素:结论:在粘膜型HNC中,肿瘤较大、侵袭性较强且伴有结节转移和侵袭性组织学特征与恶病质的严重程度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
期刊最新文献
The Sublingual Gland Flap for Oral Reconstruction: Insights From a Single Institutional Experience. Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer. Risk Factors for Early Postoperative Morbidity and Mortality following Extremity Metastatic Pathologic or Impending Fracture Fixation. Differentiated Thyroid Carcinoma Long-Term Prognostic Factors. Risk Factors of Oral Squamous Cell Carcinoma with Special Emphasis on Areca Nut Usage and Its Association with Clinicopathological Parameters and Recurrence.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1