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Translation and Cross-Cultural Adaptation of the Toronto Extremity Salvage Score (TESS) for Latin American Spanish-Speaking Patients With Limb Sarcoma: Latin American Spanish TESS Adaptation. 针对拉丁美洲西班牙语肢体肉瘤患者的多伦多肢体救治评分(TESS)的翻译和跨文化改编:拉丁美洲西班牙语 TESS 适应性。
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7887845
Oscar Ceballos, Jorge Cabrolier, Begoña Chehade, Francisco Hardoy, Francisco Cortes, Ricardo Tolosa, Orlando Wevar

Background and Objectives: This study aims to translate and culturally adapt the Toronto Extremity Salvage Score (TESS) for Latin American Spanish-speaking patients, enhancing the tool's accessibility for evaluating postsurgical functional outcomes in sarcoma patients across Latin America. Methods: The TESS questionnaires for lower extremity (LE) and upper extremity (UE) were translated and adapted following international guidelines. The process included forward and backward translation, expert committee review, and pretesting with cognitive interviewing. Patients treated for bone or soft tissue tumors in LE or UE were recruited to complete the adapted questionnaires. Test-retest reliability was evaluated by having participants complete the questionnaire again 2 weeks after the initial assessment. Results: A total of 89 participants completed the questionnaires. The study found high internal consistency, with Cronbach's alpha values reaching 0.9437 for LE and 0.9402 for UE. An agreement rate of 98.4% for the global score of TESS-LE (95% confidence interval [CI]: 0.909-1.059) and 93.9% for TESS-UE (95% CI: 0.882-0.995) was observed, demonstrating strong test-retest reliability. Conclusions: The Latin American Spanish version of TESS for both lower and upper extremities is a reliable and culturally appropriate tool for assessing physical function in limb sarcoma patients. Further validation across diverse Latin American populations is encouraged to strengthen its broad applicability.

背景与目标:本研究旨在翻译多伦多肢体救治评分(TESS)并对其进行文化调整,使其适用于拉丁美洲的西班牙语患者,从而提高该工具在评估拉丁美洲肉瘤患者手术后功能预后方面的可及性。方法:下肢(LE)和上肢(UE)的 TESS 问卷按照国际指南进行了翻译和改编。整个过程包括正向和反向翻译、专家委员会审核以及认知访谈预试。我们招募了接受骨肿瘤或上肢软组织肿瘤治疗的患者来完成改编后的问卷。在初次评估两周后,让参与者再次填写问卷,以评估重测可靠性。结果:共有 89 名参与者完成了问卷。研究发现,问卷的内部一致性很高,LE 的 Cronbach's alpha 值达到 0.9437,UE 的 Cronbach's alpha 值达到 0.9402。TESS-LE 的总分一致率为 98.4%(95% 置信区间[CI]:0.909-1.059),TESS-UE 的总分一致率为 93.9%(95% 置信区间[CI]:0.882-0.995),表明测试-再测可靠性很高。结论拉丁美洲西班牙语版下肢和上肢TESS是评估肢体肉瘤患者肢体功能的一种可靠且适合当地文化的工具。我们鼓励在不同的拉美人群中进一步验证该工具,以加强其广泛的适用性。
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引用次数: 0
The Sublingual Gland Flap for Oral Reconstruction: Insights From a Single Institutional Experience. 用于口腔重建的舌下腺皮瓣:一家机构的经验启示。
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7386967
Agata Wieczorkiewicz, Joanna Kuczera, Andrei Hramyka, Krzysztof Śliwiński, Jakub Bargiel, Grażyna Wyszyńska-Pawelec, Michał Gontarz

Background: Following ablative surgery, the reconstruction of oral cavity defects is essential to ensure optimal function and aesthetically acceptable outcomes. The purpose of this study was to retrospectively analyze the effectiveness and complication rates of the sublingual gland flap (SGF) in oral soft tissue reconstruction. The procedure for harvesting SGF and the strengths and limitations of the flap are discussed. Materials and Methods: The study group consisted of 13 patients suffering from oncological diseases who underwent soft tissue reconstruction with SGF. The patient's medical charts were evaluated based on histopathological aspects, postoperative complications, and outcomes. Reconstruction of the floor of the mouth was performed in 8 patients (61.5%) and lower gingiva in 5 patients (38.5%), respectively. Results: Complete epithelialization with closure of the defect was achieved within an average of 2 weeks. The observation period ranged from 1 to 33 months, with an average duration of 11.5 months. Partial flap necrosis and ranula occurred in one patient (7.7%). Furthermore, postoperative bleeding was observed in one patient (7.7%), and wound dehiscence and abscess formation were noted in another (7.7%). Locoregional recurrence of the cancer was observed in one case (7.7%). Conclusions: The SGF is effective for achieving successful reconstruction of small- and medium-sized defects in the lower gingiva and floor of the mouth. The complication rate is relatively low.

背景:消融手术后,口腔缺损的重建对于确保最佳功能和美观效果至关重要。本研究旨在回顾性分析舌下腺皮瓣(SGF)在口腔软组织重建中的有效性和并发症发生率。本研究讨论了舌下腺皮瓣的采集过程以及该皮瓣的优势和局限性。材料和方法:研究组包括 13 名接受 SGF 软组织重建术的肿瘤患者。根据组织病理学方面、术后并发症和疗效对患者的病历进行了评估。8名患者(61.5%)进行了口底重建,5名患者(38.5%)进行了下牙龈重建。手术结果平均 2 周内缺损上皮完全闭合。观察期从 1 个月到 33 个月不等,平均为 11.5 个月。一名患者(7.7%)出现皮瓣部分坏死和溃疡。此外,一名患者(7.7%)出现术后出血,另一名患者(7.7%)出现伤口开裂和脓肿形成。有一名患者(7.7%)观察到癌症局部复发。结论SGF可成功重建下牙龈和口底的中小型缺损。并发症发生率相对较低。
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引用次数: 0
Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer. 结合泛免疫炎症指数和血红蛋白水平(PIV/Hb)的新指数能有效预测局部晚期鼻咽癌化疗后的三联征发生率
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2124006
Efsun Somay, Busra Yilmaz, Erkan Topkan, Beyza Sirin Ozdemir, Duriye Ozturk, Ali Ayberk Besen, Huseyin Mertsoylu, Ugur Selek

Purpose: To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for the prevalence of radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA-NPC) receiving concurrent chemoradiotherapy (CCRT).

Methods: Data from 228 LA-NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs ≤35 mm. Complete blood test results from the first day of CCRT were used to calculate PIV/Hb levels. A potential relationship between pretreatment PIV/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis.

Results: Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%; specificity: 86.4%; sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group than in the PIV/Hb < 68 group (58.8% vs. 3.8%; P < 0.001). Multivariate logistic regression analysis showed that a pre-CCRT PIV > 68 was independently associated with significantly higher rates of RIT.

Conclusion: Higher pretreatment levels of the novel PIV/Hb index predict increased RIT rates following definitive CCRT for LA-NPCs.

目的:评估结合泛免疫炎症指数和血红蛋白水平(PIV/Hb)的新型指数对同时接受化学放疗(CCRT)的局部晚期鼻咽癌(LA-NPC)患者放射诱发三联征(RIT)发生率的预测效力:方法: 对 228 名 LA-NPC 患者的数据进行了回顾性研究。测量最大张口度(MMO)以确认是否存在 RIT,MMO ≤35 mm 即为 RIT。CCRT 第一天的全血检验结果用于计算 PIV/Hb 水平。使用接收器操作特征(ROC)曲线分析评估了治疗前 PIV/Hb 与 RIT 状态之间的潜在关系:结果:20.2%的患者被诊断为CCRT后RIT。ROC 曲线分析确定 68.4 g/dL 为理想的 PIV/Hb 临界值,可有效地将患者分为两组(曲线下面积:94.7%;特异性:86.4%;灵敏度:87.4%)。PIV/Hb > 68 组的 RIT 发生率明显高于 PIV/Hb P < 0.001 组)。多变量逻辑回归分析显示,CCRT前PIV>68与RIT发生率明显较高独立相关:结论:新型 PIV/Hb 指数的预处理水平越高,预示着 LA-NPCs 确诊 CCRT 后的 RIT 率越高。
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引用次数: 0
Risk Factors for Early Postoperative Morbidity and Mortality following Extremity Metastatic Pathologic or Impending Fracture Fixation. 四肢转移性病理性骨折或即将发生的骨折固定术后早期发病率和死亡率的风险因素。
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3565134
Patrick Qi Wang, Brynn P Charron, Kalter Hali, Matthew Raleigh, Christopher Del Balso, Mark D Macleod, David W Sanders, Abdel-Rahman Lawendy

Background: As cancer survivorship continues to improve, the perioperative morbidity and mortality following surgical treatment of metastatic bone disease become an increasingly important consideration. The objective of this study is to identify risk factors for early postoperative complications and mortality following extremity prophylactic fixation and pathologic fracture stabilization.

Methods: A single-centre retrospective review of 185 patients (226 total surgeries) who underwent prophylactic fixation or pathologic fracture stabilization for extremity metastatic bone disease between 2005 and 2020 was performed. Skull, spine, pelvic, and revision surgeries along with diagnosis of primary bone neoplasm were excluded. Univariate, multivariate, and subgroup analyses were performed to identify predictors and independent risk factors for 30-day postoperative morbidity and mortality.

Results: Primary cancers included lung (n = 41), breast (n = 36), multiple myeloma (n = 35), prostate (n = 16), lymphoma (n = 11), renal cell carcinoma (n = 10), and other (n = 36). The 30-day postoperative complication and mortality rates were 32.30% (n = 73) and 17.26% (n = 39), respectively. The most common complications were pulmonary-related, cardiac events, surgical site infection, sepsis, and thromboembolism. Pathologic fracture, presence of extra-skeletal metastases, longer surgical duration, and blood transfusion requirements were associated with 30-day postoperative complications overall. A past medical history for cardiac disease was also associated with systemic but not local surgical complications. Pathologic fracture, presence of extra-skeletal metastases, lung cancer, blood transfusion requirements, and increasing pack-year smoking history were predictors for 30-day mortality. In the multivariate analysis, pathologic fracture (p=0.016) and presence of extra-skeletal metastases (p=0.029) were independent predictors of complications. For mortality, pathologic fracture (p=0.014), presence of extra-skeletal metastases (p=0.0085), and increased blood transfusion requirements (p=0.048) were independent risk factors.

Conclusions: The findings of this study provide additional guidance for perioperative risk assessment and patient counselling. Additionally, improving clinical assessment tools to identify and quantify patients at risk of pathologic fractures becomes increasingly important given the significant morbidity and mortality associated with pathologic fracture treatment.

背景:随着癌症生存率的不断提高,转移性骨病手术治疗后的围手术期发病率和死亡率成为越来越重要的考虑因素。本研究旨在确定四肢预防性固定和病理性骨折稳定术后早期并发症和死亡率的风险因素:对 2005 年至 2020 年期间因四肢转移性骨病接受预防性固定或病理性骨折稳定术的 185 例患者(共 226 例手术)进行了单中心回顾性研究。颅骨、脊柱、骨盆和翻修手术以及原发性骨肿瘤诊断均被排除在外。进行了单变量、多变量和亚组分析,以确定术后30天发病率和死亡率的预测因素和独立风险因素:原发性癌症包括肺癌(41 例)、乳腺癌(36 例)、多发性骨髓瘤(35 例)、前列腺癌(16 例)、淋巴瘤(11 例)、肾细胞癌(10 例)和其他癌症(36 例)。术后 30 天的并发症和死亡率分别为 32.30%(73 例)和 17.26%(39 例)。最常见的并发症是肺部相关并发症、心脏事件、手术部位感染、败血症和血栓栓塞。病理性骨折、存在骨骼外转移瘤、手术时间较长以及需要输血与术后30天的总体并发症有关。既往心脏病史也与全身性手术并发症有关,但与局部手术并发症无关。病理性骨折、存在骨骼外转移瘤、肺癌、需要输血以及吸烟年数增加是30天死亡率的预测因素。在多变量分析中,病理性骨折(p=0.016)和骨骼外转移(p=0.029)是并发症的独立预测因素。就死亡率而言,病理性骨折(p=0.014)、存在骨骼外转移瘤(p=0.0085)和输血需求增加(p=0.048)是独立的风险因素:本研究结果为围术期风险评估和患者咨询提供了更多指导。此外,鉴于病理性骨折治疗带来的巨大发病率和死亡率,改进临床评估工具以识别和量化有病理性骨折风险的患者变得越来越重要。
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引用次数: 0
Differentiated Thyroid Carcinoma Long-Term Prognostic Factors. 分化型甲状腺癌的长期预后因素
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1067447
Pacheco-Ojeda Luis, Martínez-Jaramillo Ana Lucía, Romo-Castillo Hugo, Recalde-Maldonado Ramiro, Cañizares-Quisiguiña Stalin

Introduction: Thyroid cancer is the most common cancer in women in Ecuador.

Objective: The aim of this study was to determine the demographics and clinical and treatment variables of patients with papillary or follicular thyroid cancer, referred to as differentiated thyroid cancer (DTC), treated at a third-level hospital in Quito, Ecuador.

Methods: We reviewed retrospectively the medical records of patients with DTC, who underwent surgical treatment, from 1990 to 2019. Data included demographics, pathological information, clinical stage, type of surgery, and radioactive iodine (RAI) adjuvant therapy. Patients were monitored for up to 29 years (median follow-up time 6.9 years).

Results: The corrected overall 5-, 10-, 20-, and 30-year survival rates (Kaplan-Meier) were 93%, 85%, 70%, and 63%, respectively. On univariate analysis, age, histological type, tumor grade, histological variants, capsular invasion, vascular invasion, tumor size, clinical stage, distant metastases at diagnosis, surgical margins, extrathyroidal invasion, radioactive iodine adjuvant treatment, and locoregional recurrence were found to be significant prognostic factors. In a multivariate analysis, the following independent variables: age over 55 years, extrathyroidal spread, metastasis at diagnosis, and stage II to IV raised the risk of death (hazard risk) (HR).

Conclusions: Age over 55 years, extrathyroidal spread, metastasis at diagnosis, and advanced clinical stage were found to have a harmful prognosis and an increased risk of death in a series of Ecuadorian patients surgically treated for a DTC.

简介:甲状腺癌是厄瓜多尔妇女最常见的癌症:甲状腺癌是厄瓜多尔妇女最常见的癌症:本研究旨在确定在厄瓜多尔基多一家三级医院接受治疗的甲状腺乳头状癌或滤泡状癌(简称分化型甲状腺癌(DTC))患者的人口统计学特征、临床和治疗变量:我们回顾性地查阅了1990年至2019年接受手术治疗的DTC患者的病历。数据包括人口统计学、病理学信息、临床分期、手术类型和放射性碘(RAI)辅助治疗。对患者进行了长达29年的监测(中位随访时间为6.9年):经校正的5年、10年、20年和30年总生存率(Kaplan-Meier)分别为93%、85%、70%和63%。单变量分析发现,年龄、组织学类型、肿瘤分级、组织学变异、囊腔侵犯、血管侵犯、肿瘤大小、临床分期、诊断时远处转移、手术切缘、甲状腺外侵犯、放射性碘辅助治疗和局部复发是重要的预后因素。在多变量分析中,以下自变量提高了死亡风险(危险风险):55岁以上、甲状腺外扩散、诊断时的转移以及II期至IV期:结论:在一系列接受DTC手术治疗的厄瓜多尔患者中,年龄超过55岁、甲状腺外转移、确诊时有转移以及临床分期较晚都会对预后不利并增加死亡风险。
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引用次数: 0
Risk Factors of Oral Squamous Cell Carcinoma with Special Emphasis on Areca Nut Usage and Its Association with Clinicopathological Parameters and Recurrence. 口腔鳞状细胞癌的风险因素,特别强调阿月浑子的使用及其与临床病理参数和复发的关系。
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9725822
Atif Ali Hashmi, Ghazala Mudassir, Khushbakht Rashid, Umair Arshad Malik, Shamail Zia, Fazail Zia, Muhammad Irfan

Introduction: Oral squamous cell carcinoma (OSCC) is the most prevalent type of head and neck cancer and is associated with high mortality, particularly in Southeast Asian countries. Areca nut usage, smoking, and alcohol consumption are the most common risk factors for OSCC. Areca nut chewing is highly prevalent in Pakistan and has been attributed to an increase in OSCC cases. This study aimed to determine the association between areca nut usage and various clinicopathological features of OSCC and further evaluate the association of clinicopathological parameters of OSCC with tumor recurrence.

Materials and methods: The study was conducted using the data of 228 patients with OSCC resected at Liaquat National Hospital, Karachi, Pakistan, over 5 years between 2018 and 2022. Clinicopathological data were collected from hospital archives, and associations between various risk factors and clinicopathological parameters were determined.

Results: Males were more commonly affected (77.2%), and the most common age group was <50 years (54.4%). Areca nut usage was reported in 59.6% of cases, and the buccal mucosa was the most common site (62.7%). Areca nut usage was significantly associated with male gender, greater tumor size, greater depth of invasion (DOI), higher tumor stage, nodal stage, presence of perineural invasion (PNI), and recurrence. In addition, multivariate analysis revealed that OSCC recurrence was significantly associated with older age, larger tumor size and DOI, nodal metastasis, and areca nut usage.

Conclusion: Areca nut-related OSCCs were associated with poor prognosis and recurrence in our study population. Furthermore, OSCC recurrence was associated with various clinicopathological parameters, such as larger tumor size, a higher DOI, and nodal metastasis.

简介口腔鳞状细胞癌(OSCC)是头颈部癌症中最常见的一种,死亡率很高,尤其是在东南亚国家。咀嚼阿月浑子、吸烟和饮酒是口腔鳞状细胞癌最常见的风险因素。咀嚼阿月浑子在巴基斯坦非常普遍,也是导致 OSCC 病例增加的原因之一。本研究旨在确定咀嚼槟榔与 OSCC 的各种临床病理特征之间的关系,并进一步评估 OSCC 的临床病理参数与肿瘤复发之间的关系:该研究使用了2018年至2022年5年间在巴基斯坦卡拉奇利亚卡特国立医院切除的228例OSCC患者的数据。从医院档案中收集了临床病理数据,并确定了各种风险因素与临床病理参数之间的关联:男性患者较多(77.2%),最常见的年龄组是结论组:在我们的研究人群中,与亚麻仁相关的 OSCC 与预后不良和复发有关。此外,OSCC复发与各种临床病理参数有关,如肿瘤体积较大、DOI较高和结节转移。
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引用次数: 0
Cost-Effectiveness of Routine Histopathological Analysis of Doughnuts after Colorectal Surgery Three-Year Single-Centre Experience. 结肠直肠手术后甜甜圈常规组织病理学分析的成本效益 三年单中心经验
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-08-19 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9837336
Masood Ur Rehman, Reem Moussa, Cindy Siaw Lin, Naeem Ahmed, Abdul Rehman, Kamran Malik, Jamil Ahmed

Aim: This study aimed to assess the impact of routine histological examination of stapled colorectal anastomotic doughnuts in patients undergoing rectal cancer surgery (RCS). Justification of biopsy examination could form part of the strategies of NHS net zero practice with effort to reduce wastage and carbon footprint.

Method: A data analysis of all patients undergoing RCS during 2019-2021 at our institute was performed. We also analysed the cost of preparing and reviewing histology slides.

Results: 52 patients underwent anterior resection during the aforementioned period. Doughnuts were sent in 37 (71%) patients. 23 (62%) patients were male, and 14 (38%) were female. The median age at diagnosis was 68 (range 54-84) years. All resected specimens were adenocarcinomas. Of the 37 patients, 18 (49%) underwent low anterior resection and 19 (51%) underwent high anterior resection. Proximal doughnuts were sent in 26 (70%) patients, whereas distal doughnuts were sent in all cases. Mean distal microscopic resection margin from tumour was 22 mm (range 6-45 mm). Each doughnut required 3 slides, each costing £50 and requiring 82 minutes to fix and read. This incurred a cost of £13,650 and required 19,656 hours of preparation time. All of the doughnuts as well as resection margins were negative for malignancy.

Conclusion: Routine histopathological examination of doughnuts is time and cost-intensive however provides little or no clinical value (particularly analysis of the proximal doughnut). Distal doughnuts should only be sent for histological examination in exceptional circumstances.

目的:本研究旨在评估对接受直肠癌手术(RCS)的患者进行常规结直肠吻合口活检组织学检查的影响。活检检查的合理性可成为英国国家医疗服务体系(NHS)净零实践战略的一部分,努力减少浪费和碳足迹:方法:我们对本研究所 2019-2021 年期间接受直肠癌手术的所有患者进行了数据分析。我们还分析了准备和审查组织学切片的成本:结果:52 名患者在上述期间接受了前部切除术。37例(71%)患者送去了甜甜圈。23例(62%)患者为男性,14例(38%)为女性。确诊时的中位年龄为 68 岁(54-84 岁)。所有切除标本均为腺癌。在37名患者中,18人(49%)接受了低位前切除术,19人(51%)接受了高位前切除术。26例(70%)患者接受了近端切除,而所有病例都接受了远端切除。肿瘤远端显微切除边缘平均为 22 毫米(范围为 6-45 毫米)。每个甜甜圈需要 3 张切片,每张 50 英镑,固定和读片需要 82 分钟。这需要 13,650 英镑的成本和 19,656 小时的准备时间。所有切片以及切除边缘的恶性肿瘤均为阴性:甜甜圈的常规组织病理学检查需要大量时间和成本,但几乎没有临床价值(尤其是对近端甜甜圈的分析)。只有在特殊情况下,才应将远端甜甜圈送去进行组织病理学检查。
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引用次数: 0
Transanal Intubation for Preventing Colorectal Anastomotic Failure. 经肛门插管预防大肠吻合失败
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-08-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5562420
Mykola Gordiichuk

Introduction: Failure of low colorectal anastomosis remains challenging in surgical oncology, necessitating the exploration of new methods and improvements in existing preventive measures.

Materials and methods: This prospective study was conducted in two stages: intraluminal pressure in the colon was monitored in 32 patients by manometry and sonography over a 5-day postoperative period; 213 patients who underwent anterior resection of the rectum were analyzed, of whom 126 and 87 underwent diverting stoma (DS) and transanal intubation (TAI), respectively.

Results: The effectiveness of the recommended technique for applying and removing transanal intubation (TAI) to prevent pneumo hydro strike (≥15 kPa) on the anastomosis line was analyzed in 87 patients and compared with imposed DS. TAI showed better borderline statistical significance (p = 0.051). The incidence of repeat surgery for anastomotic failure (AL) was seven (5.55%) and four (4.59%) in the DS and TAI groups, respectively. The distance of the anastomosis from the dentate line <60 mm was associated with a higher risk of AL occurrence (odds ratio (OR), 1.012; 95% confidence interval (CI), 1.007-1.017; p < 0.001; area under the curve (AUC) = 0.82). DS is recommended for men, as the risk of AL is significantly lower among women (OR, 0.41; 95% CI, 0.16-1.04; p = 0.062; AUC, 0.61; 95% CI, 0.54-0.67).

Conclusions: Although TAI is advantageous over DS for preventing AL, surgeons select the method for the preventive approach based on the preoperative and intraoperative results.

导言:低位结肠直肠吻合术失败仍然是肿瘤外科面临的挑战,因此有必要探索新的方法并改进现有的预防措施:这项前瞻性研究分两个阶段进行:在术后 5 天内通过测压计和超声波检查对 32 名患者的结肠腔内压力进行监测;对 213 名接受直肠前切除术的患者进行分析,其中 126 人和 87 人分别接受了分流造口(DS)和经肛插管(TAI)术:结果:分析了 87 例患者采用经肛门插管(TAI)和经肛门插管(DS)的效果,并将两者进行了比较。TAI显示出更好的边缘统计学意义(P = 0.051)。DS 组和 TAI 组因吻合失败(AL)而再次手术的发生率分别为 7 例(5.55%)和 4 例(4.59%)。吻合口与齿状线的距离 p < 0.001;曲线下面积 (AUC) = 0.82)。建议男性接受 DS,因为女性的 AL 风险明显较低(OR,0.41;95% CI,0.16-1.04;p = 0.062;AUC,0.61;95% CI,0.54-0.67):尽管TAI在预防AL方面比DS更有优势,但外科医生会根据术前和术中结果选择预防方法。
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引用次数: 0
Histopathologic Features of Mucosal Head and Neck Cancer Cachexia. 头颈部黏膜癌 "头痛症 "的组织病理学特征
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5339292
Alexander J Jones, Leah J Novinger, Andrea Bonetto, Kyle P Davis, Marelle M Giuliano, Avinash V Mantravadi, Michael W Sim, Michael G Moore, Jessica A Yesensky

Objective: Determine the histopathologic features that correlate with head and neck cancer (HNC) cachexia.

Methods: A single-institution, retrospective study was performed on adults with HPV-negative, mucosal squamous cell carcinoma of the aerodigestive tract undergoing resection and free flap reconstruction from 2014 to 2019. Patients with distant metastases were excluded. Demographics, comorbidities, preoperative nutrition, and surgical pathology reports were collected. Comparisons of histopathologic features and cachexia severity were made.

Results: The study included 222 predominantly male (64.9%) patients aged 61.3 ± 11.8 years. Cachexia was identified in 57.2% patients, and 18.5% were severe (≥15% weight loss). No differences in demographics were identified between the groups. Compared to control, patients with severe cachexia had lower serum hemoglobin (p=0.048) and albumin (p < 0.001), larger tumor diameter (p < 0.001), greater depth of invasion (p < 0.001), and elevated proportions of pT4 disease (p < 0.001), pN2-N3 disease (p=0.001), lymphovascular invasion (p=0.009), and extranodal extension (p=0.014). Multivariate logistic regression identified tumor size (OR [95% CI] = 1.36 [1.08-1.73]), oral cavity tumor (OR [95% CI] = 0.30 [0.11-0.84]), and nodal burden (OR [95% CI] = 1.16 [0.98-1.38]) as significant histopathologic contributors of cancer cachexia.

Conclusions: Larger, more invasive tumors with nodal metastases and aggressive histologic features are associated with greater cachexia severity in mucosal HNC.

目的:确定与头颈癌(HNC)恶病质相关的组织病理学特征:确定与头颈癌(HNC)恶病质相关的组织病理学特征:2014年至2019年期间,对接受切除术和游离皮瓣重建术的HPV阴性成人消化道粘膜鳞状细胞癌患者进行了一项单一机构的回顾性研究。排除了有远处转移的患者。研究人员收集了患者的人口统计学资料、合并症、术前营养状况和手术病理报告。对组织病理学特征和恶病质严重程度进行了比较:研究共纳入 222 名男性患者(64.9%),年龄为 61.3 ± 11.8 岁。57.2%的患者出现恶病质,18.5%为重度恶病质(体重下降≥15%)。两组患者的人口统计学特征无差异。与对照组相比,重度恶病质患者的血清血红蛋白(p=0.048)和白蛋白(p<0.001)更低,肿瘤直径更大(p<0.001),浸润深度更深(p<0.001),pT4病变(p<0.001)、pN2-N3病变(p=0.001)、淋巴管浸润(p=0.009)和结节外扩展(p=0.014)的比例更高。多变量逻辑回归确定肿瘤大小(OR [95% CI] = 1.36 [1.08-1.73])、口腔肿瘤(OR [95% CI] = 0.30 [0.11-0.84])和结节负荷(OR [95% CI] = 1.16 [0.98-1.38])是导致癌症恶病质的重要组织病理学因素:结论:在粘膜型HNC中,肿瘤较大、侵袭性较强且伴有结节转移和侵袭性组织学特征与恶病质的严重程度有关。
{"title":"Histopathologic Features of Mucosal Head and Neck Cancer Cachexia.","authors":"Alexander J Jones, Leah J Novinger, Andrea Bonetto, Kyle P Davis, Marelle M Giuliano, Avinash V Mantravadi, Michael W Sim, Michael G Moore, Jessica A Yesensky","doi":"10.1155/2024/5339292","DOIUrl":"10.1155/2024/5339292","url":null,"abstract":"<p><strong>Objective: </strong>Determine the histopathologic features that correlate with head and neck cancer (HNC) cachexia.</p><p><strong>Methods: </strong>A single-institution, retrospective study was performed on adults with HPV-negative, mucosal squamous cell carcinoma of the aerodigestive tract undergoing resection and free flap reconstruction from 2014 to 2019. Patients with distant metastases were excluded. Demographics, comorbidities, preoperative nutrition, and surgical pathology reports were collected. Comparisons of histopathologic features and cachexia severity were made.</p><p><strong>Results: </strong>The study included 222 predominantly male (64.9%) patients aged 61.3 ± 11.8 years. Cachexia was identified in 57.2% patients, and 18.5% were severe (≥15% weight loss). No differences in demographics were identified between the groups. Compared to control, patients with severe cachexia had lower serum hemoglobin (<i>p</i>=0.048) and albumin (<i>p</i> < 0.001), larger tumor diameter (<i>p</i> < 0.001), greater depth of invasion (<i>p</i> < 0.001), and elevated proportions of pT4 disease (<i>p</i> < 0.001), pN2-N3 disease (<i>p</i>=0.001), lymphovascular invasion (<i>p</i>=0.009), and extranodal extension (<i>p</i>=0.014). Multivariate logistic regression identified tumor size (OR [95% CI] = 1.36 [1.08-1.73]), oral cavity tumor (OR [95% CI] = 0.30 [0.11-0.84]), and nodal burden (OR [95% CI] = 1.16 [0.98-1.38]) as significant histopathologic contributors of cancer cachexia.</p><p><strong>Conclusions: </strong>Larger, more invasive tumors with nodal metastases and aggressive histologic features are associated with greater cachexia severity in mucosal HNC.</p>","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":"2024 ","pages":"5339292"},"PeriodicalIF":1.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Colon in Isolated Intestinal Transplantation: Description of 4 Cases. 结肠在孤立肠移植中的作用:4 个病例的描述。
IF 1.6 Q4 ONCOLOGY Pub Date : 2024-06-14 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1910430
Pierpaolo Di Cocco, Giulia Bencini, Alessandro Martinino, Egor Petrochenkov, Stepan Akshelyan, Kentaro Yoshikawa, Mario Spaggiari, Jorge Almario-Alvarez, Ivo Tzvetanov, Enrico Benedetti

Intra-abdominal desmoid tumors are a rare and complex clinical problem. These tumors are locally invasive, and surgical ablation represents the mainstay of treatment. When localized at the root of the mesentery, their resection may require extensive excision of the intestine resulting in intestinal failure and life-long total parenteral nutrition. Intestinal transplantation, either autotransplantation or allotransplantation, has been used as a viable option to treat this group of patients. Herein, we describe a series of 4 patients with unresectable intra-abdominal desmoid tumor who underwent cadaveric isolated intestinal and ascending colon transplantation.

腹腔内蝶形肿瘤是一种罕见而复杂的临床问题。这些肿瘤具有局部侵袭性,手术消融是治疗的主要方法。如果肿瘤位于肠系膜根部,切除时可能需要大范围切除肠道,导致肠功能衰竭和终身全肠外营养。肠道移植,无论是自体移植还是异体移植,一直是治疗这类患者的可行方案。在此,我们介绍了一系列接受尸体离体肠道和升结肠移植手术的 4 例腹腔内无法切除的类脂样肿瘤患者。
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引用次数: 0
期刊
International Journal of Surgical Oncology
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