Molecularly imprinted polymers in the analysis of chlorogenic acid: A review

IF 2.6 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS Analytical biochemistry Pub Date : 2024-07-11 DOI:10.1016/j.ab.2024.115616

Himshweta , Neelam Verma , Nitu Trehan , Minni Singh

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Abstract

Chlorogenic acid, a phenolic compound, is prevalent across various plant species and has been known for its pharmacological advantages. Health care experts have identified chlorogenic acid as a potential biomarker for treatment of a wide range of illnesses. Therefore, achieving efficient extraction and analysis of chlorogenic acid from plants and their products has become essential. Molecularly imprinted polymers (MIPs) are highly effective adsorbent for the extraction of chlorogenic acid from complex matrices. Currently, there is a lack of comprehensive review article that consolidate the methods utilized for the purification of chlorogenic acid through molecular imprinting. In this context, we have surveyed the common approaches employed in preparing MIPs specifically designed for the analysis of chlorogenic acid, including both conventional and newly developed. This review discusses the advantages, limitations of polymerization techniques and proposed strategies to produce more efficient MIPs for chlorogenic acid enrichment in complex samples. Additionaly, we present advanced imprinting methods for designing MIPs, which improve the adsorption capacity, sensitivity and selectivity towards chlorogenic acid.

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分子印迹聚合物在绿原酸分析中的应用：综述。

绿原酸是一种酚类化合物，普遍存在于各种植物物种中，因其药理优势而闻名。保健专家已将绿原酸确定为治疗多种疾病的潜在生物标志物。因此，从植物及其产品中高效提取和分析绿原酸变得至关重要。分子印迹聚合物（MIPs）是从复杂基质中提取绿原酸的高效吸附剂。目前，还缺乏一篇全面的综述文章来综合介绍通过分子印迹法提纯绿原酸的方法。在此背景下，我们调查了制备专门用于分析绿原酸的分子印迹的常用方法，包括传统方法和新开发的方法。本综述讨论了聚合技术的优势和局限性，以及为在复杂样品中富集绿原酸而制备更高效 MIPs 的建议策略。此外，我们还介绍了设计 MIPs 的先进压印方法，这些方法可提高对绿原酸的吸附能力、灵敏度和选择性。

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来源期刊

Analytical biochemistry 生物-分析化学

CiteScore

5.70

自引率

0.00%

发文量

283

审稿时长

44 days

期刊介绍： The journal''s title Analytical Biochemistry: Methods in the Biological Sciences declares its broad scope: methods for the basic biological sciences that include biochemistry, molecular genetics, cell biology, proteomics, immunology, bioinformatics and wherever the frontiers of research take the field. The emphasis is on methods from the strictly analytical to the more preparative that would include novel approaches to protein purification as well as improvements in cell and organ culture. The actual techniques are equally inclusive ranging from aptamers to zymology. The journal has been particularly active in: -Analytical techniques for biological molecules- Aptamer selection and utilization- Biosensors- Chromatography- Cloning, sequencing and mutagenesis- Electrochemical methods- Electrophoresis- Enzyme characterization methods- Immunological approaches- Mass spectrometry of proteins and nucleic acids- Metabolomics- Nano level techniques- Optical spectroscopy in all its forms. The journal is reluctant to include most drug and strictly clinical studies as there are more suitable publication platforms for these types of papers.