Wael Naeem, Ahmed K.Abbas, Labiba K.Elsayed, Ahmed Goda Helal, H. Khatab, omar k.Naser, Ali A. Bendary
{"title":"Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid","authors":"Wael Naeem, Ahmed K.Abbas, Labiba K.Elsayed, Ahmed Goda Helal, H. Khatab, omar k.Naser, Ali A. Bendary","doi":"10.21608/bmfj.2024.259420.1992","DOIUrl":null,"url":null,"abstract":"Background: Uterine leiomyoma represents over 75% of the amiable tumours in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue. The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway. Aim of this study: to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus. Patients and methods: This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination. Results: endometrial thickness was ˃10mm in 69.2% of premenopausal and ˃5mm in 83%of postmenopausal. endometrial hyperplasia is the commonest glandular endometrial change represent (37.5%), complex hyperplasia without atypia 5%, simple hyperplasia with atypia 5% and proliferative endometrium 22.5%of all review bunch. in premenopausal patients hyperplasia with atypia related with the most elevated E2 level ( 252,6 pg) , complex hyperplasia without atypia with E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ± 12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level (245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) . Conclusion : there is correlation between serum oestrogen level , histopathological changes of endometrium and symptomatic fibroid uterus at perimenopausal age .","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"59 11","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Benha Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/bmfj.2024.259420.1992","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Uterine leiomyoma represents over 75% of the amiable tumours in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue. The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway. Aim of this study: to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus. Patients and methods: This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination. Results: endometrial thickness was ˃10mm in 69.2% of premenopausal and ˃5mm in 83%of postmenopausal. endometrial hyperplasia is the commonest glandular endometrial change represent (37.5%), complex hyperplasia without atypia 5%, simple hyperplasia with atypia 5% and proliferative endometrium 22.5%of all review bunch. in premenopausal patients hyperplasia with atypia related with the most elevated E2 level ( 252,6 pg) , complex hyperplasia without atypia with E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ± 12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level (245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) . Conclusion : there is correlation between serum oestrogen level , histopathological changes of endometrium and symptomatic fibroid uterus at perimenopausal age .