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Impact of Metabolic Associated Fatty Liver Disease on Health-Related Quality of Life 代谢相关性脂肪肝对健康相关生活质量的影响
Pub Date : 2024-07-16 DOI: 10.21608/bmfj.2024.289042.2078
E. Said, Yaser Mahroos Fouad, Y. Abo-Amer, Mohammed Soliman Zidan, Alaa Kandil
Introduction : Metabolic associated fatty liver disease (MAFLD), the nomenclature major benefit is the shift towards a diagnosis of inclusion based on the presence of metabolic dysfunction. MAFLD has also been associated with impaired health-related quality of life (HRQOL). Aim : to assess the impact of MAFLD & degree of hepatic steatosis and fibrosis on patients’ HRQOL applying the SF-36 Questionnaire. Methods : This cross sectional study was carried out on 250 adult who were subdivided into 2 groups, Group I (GI) comprised 150 consecutive patients with MAFLD while Group II (GII) comprised 100 apparently healthy subjects. Both studied groups had completed the short form-36 (SF-36) questionnaire. Results : The mean age among cases group was 43.6 ±10.5 years & females were the predominant. There was a highly statistical significance negative correlation between body mass index (BMI) and all domains of SF-36 questionnaire among GI. Scores of all scales of SF-36 were significantly lower in GI compared to GII). Hepatic steatosis grades with in GI according to CAP values were S1(17.3%), S2(37.3%) and S3(45.3). scores of all scales of SF-36 were significantly lower in S3 patients compared to S2 & S1(P value<0.001). Fibrosis stages within GI according to LSM values were F0(44.7%), F1(32.7%), F2(12.7%), F3(6.7%) & F4(3.3%). scores of all scales of SF-36 were significantly lower in F4 patients compared to F3, F2, F1 & F0(P value<0.001). Conclusion : HRQOL is
导言:代谢相关性脂肪肝(MAFLD),其命名的主要好处是转向以存在代谢功能障碍为基础的诊断。代谢相关性脂肪肝还与健康相关生活质量(HRQOL)受损有关。目的:采用 SF-36 问卷评估 MAFLD 及肝脏脂肪变性和纤维化程度对患者 HRQOL 的影响。方法:这项横断面研究将 250 名成人分为两组,第一组(GI)包括 150 名肝脏脂肪肝患者,第二组(GII)包括 100 名表面健康的受试者。两组受试者均填写了短表-36(SF-36)问卷。结果:病例组的平均年龄为(43.6 ± 10.5)岁,女性居多。体质指数(BMI)与 SF-36 问卷的所有领域之间存在高度统计学意义上的负相关。与 GII 相比,GI 的 SF-36 所有量表得分都明显较低。)与 S2 和 S1 相比,S3 患者的 SF-36 所有量表得分均明显较低(P 值<0.001)。与 F3、F2、F1 和 F0 相比,F4 患者的 SF-36 所有量表得分均明显较低(P 值<0.001)。结论
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引用次数: 0
Comparing Fair Control of Hyperglycemia contrary to Intensive Control in Patients after Coronary Artery Bypass Grafting Procedure 冠状动脉旁路移植术后患者高血糖的合理控制与强化控制的比较
Pub Date : 2024-07-10 DOI: 10.21608/bmfj.2024.284281.2064
Ahmed sobhy omara, Y. A. Shaheen, R. R. Abdulhafez, Mohammed Abd-elmaksoud Mohammed, Ahmed Ibrahim El-douskey
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引用次数: 0
Comparison of the Onset Time between 0.25% Bupivacaine and 0.5% Bupivacaine for Ultrasound‑Guided Infraclavicular Brachial Plexus Block: A Randomized Clinical Trial 超声引导下锁骨下臂丛神经阻滞中 0.25% 布比卡因与 0.5% 布比卡因起效时间的比较:随机临床试验
Pub Date : 2024-07-10 DOI: 10.21608/bmfj.2024.279099.2050
A. Elnoury, Y. Dabour, Mahmoud M Elnady
Background: Infraclavicular brachial plexus block is a suitable regional anaesthesia technique for hand, wrist and elbow operations and it is usually performed in conjunction with nerve stimulation. We aimed to compare the onset times of sensory block with equipotential 0.25% bupivacaine and 0.5% bupivacaine. Methods: This prospective double-blinded randomized controlled study was conducted on 60 patients, aged > 18 years, with ASA physical status I–III, and scheduled for upper extremity surgery with infraclavicular brachial plexus block. The participants were randomized into two equal groups; group I in which ICB performed with 0.25%, 20 mL bupivacaine and group II in which ICB performed with 0.5% 20 mL bupivacaine. Results: Regarding the block performance, group II showed earlier onset time and longer duration of sensory and motor blocks compared to group I (P<0.05) and the performance time was significantly shorter in in group II compared to group I (P=0.015). Number of patients required analgesia was significantly lower in group II compared to group I (P=0.003) was significantly lower in group II compared to group I (P=0.003) and the first rescue analgesic requirement was significantly delayed in group II compared to group I (P<0.001). Conclusions: We found that 0.5% bupivacaine showed earlier onset time and longer duration of sensory and motor blocks compared to 0.25% bupivacaine in infraclavicular block. Thus, when a quicker block onset is required, 0.5% bupivacaine is a better choice than 0.25% bupivacaine.
背景:锁骨下臂丛阻滞是一种适用于手、腕和肘部手术的区域麻醉技术,通常与神经刺激同时进行。我们旨在比较等电位 0.25% 布比卡因和 0.5% 布比卡因感觉阻滞的起效时间。方法:这项前瞻性双盲随机对照研究的对象是 60 名年龄大于 18 岁、ASA 身体状况 I-III 级、计划接受锁骨下臂丛神经阻滞的上肢手术患者。参与者被随机分为两组,第一组使用 0.25% 20 mL 布比卡因进行 ICB,第二组使用 0.5% 20 mL 布比卡因进行 ICB。结果:在阻滞效果方面,与第一组相比,第二组的感觉和运动阻滞起始时间更早,持续时间更长(P<0.05),与第一组相比,第二组的阻滞时间明显更短(P=0.015)。与第一组相比,第二组需要镇痛的患者人数明显较少(P=0.003),与第一组相比,第二组需要镇痛的患者人数明显较少(P=0.003),与第一组相比,第二组首次需要镇痛的时间明显延迟(P<0.001)。结论我们发现,在锁骨下阻滞中,与 0.25% 布比卡因相比,0.5% 布比卡因起效时间更早,感觉和运动阻滞持续时间更长。因此,当需要更快的阻滞起效时间时,0.5% 布比卡因比 0.25% 布比卡因是更好的选择。
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引用次数: 0
Intramedullary Nailing Versus Minmally Invasive Plate Osteosynthesis (MIPO) in Management of Distal Tibial Fractures 髓内钉与微创钢板骨整合术(MIPO)在治疗胫骨远端骨折中的应用
Pub Date : 2024-07-10 DOI: 10.21608/bmfj.2024.287818.2074
Elsayed M.M. Ibrahim, H. Farag, Mohamed A. Zahran, Saeed Adel Salama
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引用次数: 0
Correlation between serum estrogen level and endometrial histology in cases of fibroid uterus in peri-menopausal peroid 围绝经期子宫肌瘤病例中血清雌激素水平与子宫内膜组织学的相关性
Pub Date : 2024-07-09 DOI: 10.21608/bmfj.2024.259420.1992
Wael Naeem, Ahmed K.Abbas, Labiba K.Elsayed, Ahmed Goda Helal, H. Khatab, omar k.Naser, Ali A. Bendary
Background: Uterine leiomyoma represents over 75% of the amiable tumours in ladies of conceptive age amass. Endometrium is a hormonally responsive tissue. The reaction of endometrium to incitement by endogenous or exogenous steroid hormones is unsurprising endogenous reaction is an impression of the hypothalamic–pituitary-ovarian pathway. Aim of this study: to assess serum level of E2 and study endometrial histological changes in instances of fibroid uterus. Patients and methods: This study included forty ladies have symptomatic fibroid uterus. history was taken, general examination, ultrasound examination, measuring serum estradiol and endometrial biopsy was taken by D&C or hysterectomy sent for histopathological examination. Results: endometrial thickness was ˃10mm in 69.2% of premenopausal and ˃5mm in 83%of postmenopausal. endometrial hyperplasia is the commonest glandular endometrial change represent (37.5%), complex hyperplasia without atypia 5%, simple hyperplasia with atypia 5% and proliferative endometrium 22.5%of all review bunch. in premenopausal patients hyperplasia with atypia related with the most elevated E2 level ( 252,6 pg) , complex hyperplasia without atypia with E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ± 12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level (245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) . Conclusion : there is correlation between serum oestrogen level , histopathological changes of endometrium and symptomatic fibroid uterus at perimenopausal age .
背景:在受孕年龄段女性的常见肿瘤中,子宫肌瘤占 75% 以上。子宫内膜是一种激素反应性组织。子宫内膜对内源性或外源性类固醇激素的反应不足为奇,内源性反应是下丘脑-垂体-卵巢通路的一种表现。本研究的目的:评估血清 E2 水平,研究子宫肌瘤患者的子宫内膜组织学变化。患者和方法:询问病史、进行全身检查、超声波检查、测量血清雌二醇,并通过剖腹产或子宫切除术进行子宫内膜活检,以进行组织病理学检查。结果:69.2%绝经前患者的子宫内膜厚度为˃10 毫米,83%绝经后患者的子宫内膜厚度为˃5 毫米。子宫内膜增生是最常见的子宫内膜腺体病变(37.5%),无不典型性的复杂性增生占 5%,有不典型性的单纯性增生占 5%,增生性子宫占 22.5%。在绝经前患者中,伴有不典型增生的子宫内膜增生与 E2 水平(252.6 pg)的升高最为相关,伴有不典型增生的复杂增生与 E2 水平(221.6 ± 6.22 SD)相关,伴有不典型增生的子宫内膜增生与 E2 水平(184.84 ± 12.11 SD)相关,而在绝经后患者中,伴有不典型增生的子宫内膜增生与 E2 水平(245.3 pg)相关,伴有不典型增生的子宫内膜增生与 E2 水平(145.68 ± 33.53 SD)相关。结论:血清雌激素水平、子宫内膜组织病理学变化与围绝经期无症状子宫肌瘤之间存在相关性。
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引用次数: 0
Accuracy of Endoscopic Ultrasound Elastography for Evaluation of Pancreatic Masses 内窥镜超声弹性成像评估胰腺肿块的准确性
Pub Date : 2024-07-09 DOI: 10.21608/bmfj.2024.278010.2044
Naglaa El-Toukhy Ramadan El-Toukhy, A. I. Abo-Elmagd, Ahmed Khaled Elgebaly, Hany Elkholy
Background: Endoscopic ultrasound elastography (EUS) is an imaging modality that has recently been proposed for the visualization and evaluation of tissue elasticity. This study aimed to assess the role of EUS elastography in the diagnosis of pancreatic mass lesions in comparison to EUS fine needle aspiration (FNA) biopsy and to differentiate between benign and malignant lesions. Methods: This was a cross-sectional study that was conducted on 53 patients are coming to hospital suspected to have pancreatic mass clinically (jaundice, cachexia epigastric pain) or radiological (ultrasound, Computed tomography (CT) and/or Magnetic resonance imaging (MRI) of the abdomen). EUS was done and strain ratio was calculated and fine needle aspiration was done for histopathological examination. Results: Regarding the Pancreatic FL on EUS elastography was hard in 42 (79.25%) patients and soft in 11 (20.75%) patients. Strain ratio of hard Pancreatic FL was significantly higher than soft Pancreatic FL. The type of lesion by histopathological examination, 37(69.81%) patients had adenocarcinoma, 11(20.75%) patients had chronic pancreatitis and 5(9.4%) had neuroendocrinal tumors. EUS-strain ratio can significantly predict the type of Pancreatic FL (malignant or benign) with AUC =0.909, with 100 % sensitivity, 100%specificity, 98%PPV and 93.7%NPV, P value <0.05. There is high concordance between Endoscopic Ultrasound Elastography and biopsy outcomes, as indicated by a Concordance Correlation Coefficient (0.95). Conclusion: FNA biopsy can be replaced by EUS elastography in diagnosis of pancreatic masse and distinction of benign and malignancy
背景:内镜超声弹性成像(EUS)是最近提出的一种成像方式,用于观察和评估组织弹性。本研究旨在评估 EUS 弹性成像与 EUS 细针穿刺活检(FNA)相比在诊断胰腺肿块病变中的作用,并区分良性和恶性病变。方法:这是一项横断面研究,研究对象是 53 名临床(黄疸、恶病质、上腹痛)或放射(腹部超声、计算机断层扫描(CT)和/或磁共振成像(MRI))怀疑患有胰腺肿块的来院患者。进行 EUS 检查并计算应变比,然后进行细针穿刺进行组织病理学检查。结果42例(79.25%)患者的胰腺FL在EUS弹性成像中呈硬性,11例(20.75%)患者呈软性。硬性胰腺纤维瘤的应变比明显高于软性胰腺纤维瘤。从组织病理学检查的病变类型来看,37 例(69.81%)患者为腺癌,11 例(20.75%)患者为慢性胰腺炎,5 例(9.4%)患者为神经内分泌肿瘤。EUS 应变比能明显预测胰腺 FL 的类型(恶性或良性),AUC =0.909,灵敏度为 100%,特异性为 100%,PPV 为 98%,NPV 为 93.7%,P 值小于 0.05。内镜超声弹性成像与活检结果之间的相关性很高,相关系数为 0.95。结论在诊断胰腺肿块和区分良性和恶性肿瘤时,EUS 弹性成像可取代 FNA 活检术
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引用次数: 0
Evaluation of Special AT-Rich Sequence-Binding Protein 2 (SATB2) Expression in Colonic Carcinoma, Immunohistochemical Study 评估结肠癌中特殊 AT 富序列结合蛋白 2 (SATB2) 的表达,免疫组化研究
Pub Date : 2024-07-09 DOI: 10.21608/bmfj.2024.274509.2033
M. Bakr, R. Amer, Marwa Saied Abd Allah, Asmaa Hassanein Elsayed
Background: Globally, colorectal cancer poses a significant oncologic challenge, with colonic carcinoma ranking as the third most prevalent cancer worldwide. In Egypt, it represents a noteworthy portion of both male and female cancer cases. The prognosis for colonic carcinoma remains poor due to the lack of early symptoms, emphasizing the need for effective biomarkers to predict prognosis and guide treatment strategies. This study aimed to evaluate SATB2 expression in colonic carcinoma by immunohistochemistry and assess correlation between SATB2 protein and clinicopathological parameters of colonic carcinoma. Methods: This retrospective study was carried out upon 50 cases of colonic adenocarcinoma obtained from the pathology department and early cancer detection unit at Benha Faculty of Medicine during the period of 2017 to 2021. Cases were selected on basis of availability of demographic data (age, sex) and clinicopathological data (Tumor site, tumor size, depth of invasion, lymph node status, grade, TNM stage, lympho-vascular invasion and presence of distant metastasis). Results : There was a highly significant inverse statistical correlation between SATB2 expression and tumor grade, depth of tumor invasion, lymph node metastasis, distant metastasis and tumor stage (P value <0.01). Also, there was a significant inverse statistical correlation between SATB2 expression and presence of lympho-vascular invasion (P value <0.05). Conclusion: SATB2 expression in colonic cancer aligns with key prognostic factors, making it a potential predictor of prognosis. Furthermore, SATB2 expression inversely correlates with tumor aggressiveness, suggesting it may indicate a favorable prognosis, while loss of SATB2 expression may imply a poorer prognosis in colonic cancer.
背景:在全球范围内,结肠直肠癌是一项重大的肿瘤挑战,结肠癌在全球癌症发病率中排名第三。在埃及,结肠癌在男性和女性癌症病例中都占有相当大的比例。由于缺乏早期症状,结肠癌的预后仍然很差,因此需要有效的生物标志物来预测预后和指导治疗策略。本研究旨在通过免疫组化评估 SATB2 在结肠癌中的表达,并评估 SATB2 蛋白与结肠癌临床病理参数的相关性。方法:这项回顾性研究的对象是 2017 年至 2021 年期间从本哈医学院病理科和早期癌症检测室获得的 50 例结肠腺癌病例。病例根据人口统计学数据(年龄、性别)和临床病理学数据(肿瘤部位、肿瘤大小、侵犯深度、淋巴结状态、分级、TNM分期、淋巴管侵犯和是否存在远处转移)的可用性进行选择。结果:SATB2的表达与肿瘤分级、肿瘤浸润深度、淋巴结转移、远处转移和肿瘤分期之间存在高度显著的统计学反相关(P值<0.01)。此外,SATB2 的表达与淋巴管侵犯之间也存在明显的统计学反相关性(P 值<0.05)。结论结肠癌中 SATB2 的表达与关键预后因素一致,因此它是预后的潜在预测因子。此外,SATB2 的表达与肿瘤的侵袭性成反比,这表明它可能预示着结肠癌的良好预后,而 SATB2 的表达缺失则可能预示着结肠癌的不良预后。
{"title":"Evaluation of Special AT-Rich Sequence-Binding Protein 2 (SATB2) Expression in Colonic Carcinoma, Immunohistochemical Study","authors":"M. Bakr, R. Amer, Marwa Saied Abd Allah, Asmaa Hassanein Elsayed","doi":"10.21608/bmfj.2024.274509.2033","DOIUrl":"https://doi.org/10.21608/bmfj.2024.274509.2033","url":null,"abstract":"Background: Globally, colorectal cancer poses a significant oncologic challenge, with colonic carcinoma ranking as the third most prevalent cancer worldwide. In Egypt, it represents a noteworthy portion of both male and female cancer cases. The prognosis for colonic carcinoma remains poor due to the lack of early symptoms, emphasizing the need for effective biomarkers to predict prognosis and guide treatment strategies. This study aimed to evaluate SATB2 expression in colonic carcinoma by immunohistochemistry and assess correlation between SATB2 protein and clinicopathological parameters of colonic carcinoma. Methods: This retrospective study was carried out upon 50 cases of colonic adenocarcinoma obtained from the pathology department and early cancer detection unit at Benha Faculty of Medicine during the period of 2017 to 2021. Cases were selected on basis of availability of demographic data (age, sex) and clinicopathological data (Tumor site, tumor size, depth of invasion, lymph node status, grade, TNM stage, lympho-vascular invasion and presence of distant metastasis). Results : There was a highly significant inverse statistical correlation between SATB2 expression and tumor grade, depth of tumor invasion, lymph node metastasis, distant metastasis and tumor stage (P value <0.01). Also, there was a significant inverse statistical correlation between SATB2 expression and presence of lympho-vascular invasion (P value <0.05). Conclusion: SATB2 expression in colonic cancer aligns with key prognostic factors, making it a potential predictor of prognosis. Furthermore, SATB2 expression inversely correlates with tumor aggressiveness, suggesting it may indicate a favorable prognosis, while loss of SATB2 expression may imply a poorer prognosis in colonic cancer.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"31 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Allicin on Schistosoma mansoni mature and immature worms 大蒜素对曼氏血吸虫成熟虫和未成熟虫的影响
Pub Date : 2024-07-08 DOI: 10.21608/bmfj.2024.287421.2073
Amany F. M. El Fakahany, Amina I. Abdelmaabood, Atef H. H. Abd El Hamid, Amira Th. M. Ali, Eman A. Abououf
Background : Garlic is this ancient medicinal plant which has a wide range of uses, including fighting against microbes, viruses, fungi, protozoa, and helminths. Allicin is the active ingredient in garlic and responsible for its antiparasitic effects. Aim of work : the current research was conducted to demonstrate the possible curative and preventative benefits of allicin on both adult and juvenile S. mansoni worms. Methods: For 96 hours, immature and adult S. mansoni worms were cultured with varying doses of allicin (25, 50, 100, and 200 µg/ml). Their motor activity and death rate were evaluated every 24 hours using light microscopy. The ultrastructural effects of allicin on worms were assessed by scanning electron microscopy. The researchers used 40 male Swiss albino mice strain CD1, divided into four groups with 10 animals in each group. Allicin was administered to three groups at varied intervals after they were infected with S. mansoni cercariae. Parasitological studies, including worm burden, oogram pattern, and tissue egg load, were used to assess the efficacy of allicin on day 54 after infection. The results: revealed a high significant difference in S. mansoni immature worms when incubated with allicin at doses of 50, 100, and 200µg/ml. Also incubating adult worms of S. mansoni with allicin at concentrations of 100µg/ml and 200µg/ml were significant. In vivo, there was non-significant impact on worm load with high significant rise in dead egg percentage. Conclusion: These data suggest that allicin is effective against S. mansoni worms in vitro, but with little impact in vivo.
背景:大蒜是一种古老的药用植物,具有广泛的用途,包括抗微生物、病毒、真菌、原生动物和蠕虫。大蒜素是大蒜的活性成分,具有抗寄生虫的作用。工作目的:目前的研究旨在证明大蒜素对曼氏沙门氏菌成虫和幼虫可能具有的治疗和预防作用。研究方法:用不同剂量的大蒜素(25、50、100 和 200 µg/ml)培养曼氏沙蚕幼虫和成虫 96 小时。每隔 24 小时用光学显微镜评估其运动活性和死亡率。扫描电子显微镜评估了大蒜素对蠕虫超微结构的影响。研究人员使用了 40 只品系为 CD1 的雄性瑞士白化小鼠,分为四组,每组 10 只。三组小鼠在感染曼氏蟠尾丝虫后,以不同的时间间隔服用大蒜素。在感染后第 54 天进行寄生虫学研究,包括虫体负荷、虫卵形态和组织卵量,以评估大蒜素的疗效。结果表明:用 50、100 和 200µg/ml 剂量的大蒜素孵化曼氏蟠尾丝虫未成熟蠕虫,其效果差异很大。此外,用浓度为 100µg/ml 和 200µg/ml 的大蒜素培养曼氏沙门氏菌成虫也有显著差异。在体内,大蒜素对蠕虫量的影响不明显,但对死卵率的影响却很明显。结论这些数据表明,大蒜素在体外对曼氏沙门氏菌有效,但在体内影响不大。
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引用次数: 0
Effect of Smoking on Macular Perfusion Using Optical Coherence Tomography Angiography 使用光学相干断层扫描血管造影术观察吸烟对黄斑灌注的影响
Pub Date : 2024-07-08 DOI: 10.21608/bmfj.2024.253620.1973
Ahmed Morsy Khalifa, A. Shebl, Mohamed Fathy Farid, Elham Abdelazem Gad
: Background: Chronic smoking's impact on ocular health remains an area of concern, particularly its effect on macular perfusion. This study aimed to evaluate the influence of long-term smoking on macular perfusion using Optical Coherence Tomography Angiography (OCTA). Methods : A prospective, randomized clinical trial was conducted at Benha University Hospital's ophthalmology division from January 2020 to December 2021. Forty participants were divided into smoking (Group 1) and control (Group 2) groups. Exclusion criteria included systemic and ocular diseases, refractive errors, retinal vasculopathies, ocular surgeries, or media opacity. OCTA assessed macular perfusion, while other ophthalmic parameters were measured. Results: The smoking group exhibited a higher smoking index (490.00±325.64) and duration (17.30±7.37 years) compared to controls. Despite comparable visual acuity and intraocular pressure between groups, smokers demonstrated significantly lower superficial and deep layer densities across various macular regions (p < 0.001). The foveal avascular zone (FAZ) area was notably larger in smokers (p < 0.001), indicating compromised perfusion. Conclusions: DCP's is more vulnerable to oxidative damage and poor perfusion brought by cigarette smoking, which led to a considerable drop in VD of DCP compared to SCP. In addition, bigger research examining the long-term effect of smoking on retinal microcirculation in the macula may help clarify the significance of smoking as a risk factor for systemic vascular diseases.
:背景:长期吸烟对眼部健康的影响,尤其是对黄斑灌注的影响,仍然是一个值得关注的领域。本研究旨在利用光学相干断层扫描血管造影术(OCTA)评估长期吸烟对黄斑灌注的影响。方法:2020 年 1 月至 2021 年 12 月,本哈大学医院眼科开展了一项前瞻性随机临床试验。40 名参与者被分为吸烟组(第 1 组)和对照组(第 2 组)。排除标准包括全身性疾病和眼部疾病、屈光不正、视网膜血管疾病、眼部手术或介质混浊。OCTA 评估黄斑灌注,同时测量其他眼科参数。结果显示与对照组相比,吸烟组的吸烟指数(490.00±325.64)和吸烟时间(17.30±7.37)均高于对照组。尽管组间视力和眼压相当,但吸烟者黄斑各区域的浅层和深层密度明显较低(P < 0.001)。吸烟者的眼窝无血管区(FAZ)面积明显更大(p < 0.001),表明灌注受到了影响。结论与 SCP 相比,DCP 更容易受到吸烟带来的氧化损伤和灌注不良的影响,这导致 DCP 的 VD 显著下降。此外,对吸烟对黄斑区视网膜微循环的长期影响进行更深入的研究,可能有助于阐明吸烟作为全身性血管疾病危险因素的意义。
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引用次数: 0
Assessment of prognostic value FOXA1 Expression in breast carcinoma after neoadjuvant chemotherapy: Immunohistochemically Study 评估新辅助化疗后乳腺癌中 FOXA1 表达的预后价值:免疫组化研究
Pub Date : 2024-07-05 DOI: 10.21608/bmfj.2024.252347.1966
A. M. Elbalshy, N. S. Zafer, Ashgan I Elsarha, Naglaa Mohammed Ahmed Elshazly
: Background: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women. Aim and objectives: to determine the expression of FOXA1 in breast carcinoma, to correlate the expression of FOXA1 with hormonal receptors (ER and PR), Her2neu, Ki67and pathological response to chemotherapy. Patient and method: This retrospective study was carried on 100 controlled, selected cases included seven cases with bilateral breast cancer, eighty-six cases IDC, five cases ILC, ductal carcinoma insitu (DCIS) was three cases, medullary carcinoma three case, two cases papillary and one case tubular. Fifty-six cases of the total cases with positive axillary lymph nodes metastasis. It was performed on formalin-fixed paraffin-embedded tissue blocks of specimens, collected from Pathology Department, Faculty of Medicine, Benha University, from the years (2013-2019). Result: Concerning the pathological response was found that, FOXA1 was positive in forty-four (44) out of fifty (50) cases with complete pathological response, twenty-seven (27) out of thirty-seven (37) cases with partial pathological response and seven (7) cases out of thirteen (13) cases with no pathological response. While for (ER), (89) cases are positive out of them (74) case FOXA1 positive, and (PR), (80) cases positive, FOXA1 positivity (68) out of them, however Her-2neu negative cases were (48) from them (41) case are FOXA1 positive. For Ki-67, fourteen (14) cases show low scoring, while (31) cases has intermediate score and (55) cases has high scoring, FOXA1 positivity out of them (14, 31, 33 cases respectively). Conclusion: FOXA1 is a marker of good prognosis in breast cancer as FOXA1 expression associated with complete pathological response, positive hormone receptors and low-intermediate Ki67.
:背景:乳腺癌是最常见的恶性肿瘤,也是女性癌症死亡的主要原因。目的和目标:确定 FOXA1 在乳腺癌中的表达,将 FOXA1 的表达与激素受体(ER 和 PR)、Her2/neu、Ki67 和化疗的病理反应相关联。患者和方法:本回顾性研究以100例对照者为研究对象,所选病例包括双侧乳腺癌7例、IDC 86例、ILC 5例、原位乳腺导管癌(DCIS)3例、髓样癌3例、乳头状癌2例、管状癌1例。其中 56 例腋窝淋巴结转移阳性。研究对象为2013-2019年期间从贝哈大学医学院病理系收集的福尔马林固定石蜡包埋组织块标本。结果在病理反应方面发现,在五十(50)例完全病理反应病例中,有四十四(44)例 FOXA1 呈阳性;在三十七(37)例部分病理反应病例中,有二十七(27)例 FOXA1 呈阳性;在十三(13)例无病理反应病例中,有七(7)例 FOXA1 呈阳性。ER阳性病例有89例,其中FOXA1阳性病例有74例;PR阳性病例有80例,其中FOXA1阳性病例有68例,但Her-2/neu阴性病例有48例,其中FOXA1阳性病例有41例。Ki-67方面,14例为低分,31例为中分,55例为高分,其中分别有14、31、33例为FOXA1阳性。结论FOXA1 是乳腺癌良好预后的标志物,因为 FOXA1 表达与完全病理反应、激素受体阳性和低中度 Ki67 相关。
{"title":"Assessment of prognostic value FOXA1 Expression in breast carcinoma after neoadjuvant chemotherapy: Immunohistochemically Study","authors":"A. M. Elbalshy, N. S. Zafer, Ashgan I Elsarha, Naglaa Mohammed Ahmed Elshazly","doi":"10.21608/bmfj.2024.252347.1966","DOIUrl":"https://doi.org/10.21608/bmfj.2024.252347.1966","url":null,"abstract":": Background: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women. Aim and objectives: to determine the expression of FOXA1 in breast carcinoma, to correlate the expression of FOXA1 with hormonal receptors (ER and PR), Her2neu, Ki67and pathological response to chemotherapy. Patient and method: This retrospective study was carried on 100 controlled, selected cases included seven cases with bilateral breast cancer, eighty-six cases IDC, five cases ILC, ductal carcinoma insitu (DCIS) was three cases, medullary carcinoma three case, two cases papillary and one case tubular. Fifty-six cases of the total cases with positive axillary lymph nodes metastasis. It was performed on formalin-fixed paraffin-embedded tissue blocks of specimens, collected from Pathology Department, Faculty of Medicine, Benha University, from the years (2013-2019). Result: Concerning the pathological response was found that, FOXA1 was positive in forty-four (44) out of fifty (50) cases with complete pathological response, twenty-seven (27) out of thirty-seven (37) cases with partial pathological response and seven (7) cases out of thirteen (13) cases with no pathological response. While for (ER), (89) cases are positive out of them (74) case FOXA1 positive, and (PR), (80) cases positive, FOXA1 positivity (68) out of them, however Her-2neu negative cases were (48) from them (41) case are FOXA1 positive. For Ki-67, fourteen (14) cases show low scoring, while (31) cases has intermediate score and (55) cases has high scoring, FOXA1 positivity out of them (14, 31, 33 cases respectively). Conclusion: FOXA1 is a marker of good prognosis in breast cancer as FOXA1 expression associated with complete pathological response, positive hormone receptors and low-intermediate Ki67.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Benha Medical Journal
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