Curbing the Obesity Epidemic: Should GLP-1 Receptor Agonists Be the Standard of Care for Obesity?

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI:10.1007/s11886-024-02097-4

Jennifer M Kaplan, Adnin Zaman, Layla A Abushamat

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Abstract

Purpose of review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.

Recent findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss. Glucagon-like peptide 1 (GLP-1) agonists and glucose-dependent insulinotropic polypeptide (GIP) agonists such as semaglutide and tirzepatide are approved by the United States Food and Drug Administration (FDA) for the management of obesity. The SELECT trial demonstrated that semaglutide led to a reduction in major adverse cardiovascular events in patients without diabetes who were either overweight and had preexisting cardiovascular disease or obese.

Summary: The treatment of obesity is critical to prevent the progression of cardiovascular-kidney-metabolic syndrome. Incretin-based therapies offer remarkable weight loss and reduce major cardiovascular adverse events.

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遏制肥胖症流行：GLP-1 受体激动剂是否应成为治疗肥胖症的标准药物？

综述目的：本文总结了肥胖症的医学治疗方法，重点介绍了针对肥胖症神经激素基础的增量素疗法：最近的研究结果：模仿增量素作用的药物能有效、持久地减轻体重，增量素是一组随营养摄入而释放的肽类激素，能调节食欲。胰高血糖素样肽1（GLP-1）激动剂和葡萄糖依赖性促胰岛素多肽（GIP）激动剂，如 semaglutide 和 tirzepatide，已被美国食品和药物管理局（FDA）批准用于治疗肥胖症。SELECT 试验表明，对于体重超重并已患有心血管疾病或肥胖的无糖尿病患者，semaglutide 可减少主要不良心血管事件的发生。摘要：肥胖症的治疗对于预防心血管-肾脏-代谢综合征的恶化至关重要。基于胰岛素的疗法可显著减轻体重，减少主要心血管不良事件的发生。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.