Clinical and Histologic Efficacy of Digitally Designed CAD/CAM Allogeneic Bone Blocks: A Prospective Cohort Study.

Abstract

The growth in bone reconstructive surgery has been unsurpassed in recent decades. However, most bone-regenerative products lack any potential for delivering site-specific morphologically driv-en augmentation. It was therefore the purpose of this study to evaluate the histologic and clinical incorporation of a novel CAD/CAM allogeneic block bone graft for the reconstruction of complex 3D alveolar defects. In addition, the clinical outcome of dental implants subsequently placed and load-ed within these grafts was assessed after up to 5 years in function. Results demonstrated that 4 of the initial 17 blocks failed (23.5%). The remaining 13 blocks plus an additional 2 replacement blocks were fully or partially incorporated within the recipient bone site (79%). Of the 32 implants placed within the integrated blocks, no failures occurred after up to 5 years in function, with a recorded mean marginal bone loss of -0.5 mm per implant.