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Biological Reset Protocol for the Regenerative Treatment of Advanced Peri-implantitis Defects: A Proof of Concept. 生物复位方案再生治疗晚期种植体周围炎缺陷:一个概念的证明。
IF 1.1 Pub Date : 2025-12-12 DOI: 10.11607/prd.7923
Andrea Ravidà, Debora R Dias, Luigi Romano, Matteo Serroni

This study presents the Biologic Reset Protocol (BRP), a reproducible workflow that integrates prosthetic and surgical phases to improve the predictability of regenerative treatment in intrabony peri-implantitis lesions. The protocol is designed to re-establish peri-implant conditions favorable to long-term tissue stability and proper implant function. The BRP is structured into three sequential phases: (1) a pre-surgical phase, involving the removal of the existing prosthesis to improve diagnostic accuracy, facilitate non-surgical decontamination, and promote soft tissue healing; (2) a regenerative surgical phase based on principles of guided bone and tissue regeneration, favoring a submerged healing approach. This phase involves meticulous implant surface decontamination using air-polishing to preserve the fixture's original biocompatibility, followed by the placement of particulate bone grafting combined, when necessary, with a stabilized membrane; and (3) a final prosthetic phase which may include prosthetic refinement or replacement to ensure biologically favorable design and prevent disease recurrence. By integrating current evidence with comprehensive biological, surgical, and prosthetic principles, the BRP offers a structured and predictable framework for the treatment of complex peri-implantitis cases, promoting both regenerative success and the long-term preservation of implant health.

本研究提出了生物重置方案(BRP),这是一个可重复的工作流程,整合了假体和手术阶段,以提高骨内种植体周围炎病变再生治疗的可预测性。该方案旨在重建种植体周围的条件,有利于长期组织稳定和适当的种植体功能。BRP分为三个连续的阶段:(1)术前阶段,包括移除现有假体以提高诊断准确性,促进非手术净化,促进软组织愈合;(2)基于引导骨和组织再生原则的再生手术阶段,倾向于水下愈合方法。这一阶段包括使用空气抛光对种植体表面进行细致的净化,以保持固定装置原有的生物相容性,然后在必要时将颗粒骨移植结合稳定膜进行放置;以及(3)最终假体阶段,其可包括假体的改进或替换,以确保生物学上有利的设计和防止疾病复发。通过将现有证据与综合的生物学、外科和假体原理相结合,BRP为复杂的种植体周围炎病例的治疗提供了一个结构化和可预测的框架,促进了再生成功和种植体健康的长期保存。
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引用次数: 0
Toothbrushing with Activated Charcoal May Stain Enamel White Spot Lesions: A 4-Year Follow-up Case Report. 用活性炭刷牙可能会染色牙釉质白斑病变:一个4年随访病例报告。
IF 1.1 Pub Date : 2025-12-12 DOI: 10.11607/prd.7964
Victor Mosquim, Karin Cristina da Silva Modena, Juliana Carvalho Jacomine, Letícia Ferreira de Freitas Brianezzi, Beatriz Medola Marun, Maria Cecília Veronezi, Maria Silvia de Lima, Giovanna Speranza Zabeu

Activated charcoal (AC)-containing products have been widely advertised over the internet, but evidence of their efficacy and safety are still scarce. Few studies have addressed their abrasivity and whitening efficacy, but none has addressed their staining potential. Therefore, this study aimed to report irreversible staining caused on enamel white spot lesions (WSLs) after orthodontic treatment caused by AC powder used for toothbrushing. A fifteen year-old patient sought the dental clinic complaining about dark discolorations on maxillary anterior teeth after toothbrushing with a fluoride-free AC powder. The patient reported that white discolorations were present after the orthodontic appliances removal and started using the product due to its 'whitening' claims. Then, due to the dark discoloration, the patient sought another dental professional who conducted microabrasion, but the stains were not completely removed. Therefore, direct veneers were conducted using self-etching adhesive system (FL Bond II) and resin composites (Beautifil II A2O, B2 and incisal) to successfully cover the remaining discoloration. After 4 years, no staining was observed. In conclusion, AC-containing products might not be safe for patients with WSL after orthodontic treatment, and their use might irreversibly stain the demineralized enamel, leading to more invasive treatments to solve the resulting discoloration.

含有活性炭(AC)的产品在互联网上被广泛宣传,但其有效性和安全性的证据仍然很少。很少有研究涉及其磨耗性和美白功效,但没有研究涉及其染色潜力。因此,本研究旨在报道AC粉刷牙对正畸治疗后牙釉质白斑病变(WSLs)的不可逆染色。一名十五岁的病人到牙科诊所求诊,抱怨用无氟AC粉刷牙后上颌前牙变黑。患者报告说,在移除正畸器具后出现白色变色,并开始使用该产品,因为它的“美白”声明。然后,由于深色变色,患者找了另一位牙科专业人员进行微磨,但污渍没有完全去除。因此,使用自蚀刻粘合剂系统(FL Bond II)和树脂复合材料(Beautifil II A2O, B2和切牙)进行直接贴面,以成功覆盖剩余的变色。4年后,未见染色。综上所述,在正畸治疗后,含有ac的产品对WSL患者可能不安全,并且它们的使用可能不可逆地染色脱矿的牙釉质,导致更多的侵入性治疗来解决由此产生的变色。
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引用次数: 0
Single Buccal Envelope Flap with Connective Tissue Graft Wall and Fibroblast Growth Factor-2 Combined with Autogenous Bone Graft for Mandibular Class III Furcation Defect: A Case Report. 结合结缔组织壁及成纤维细胞生长因子-2的单颊包膜瓣联合自体骨移植治疗下颌骨III级骨缺损1例。
IF 1.1 Pub Date : 2025-12-05 DOI: 10.11607/prd.7945
Tomoaki Kariya, Chen-Yi Lee, Takahiko Shiba, David Minjoon Kim, Takanori Iwata

During supportive periodontal care, teeth with Class III furcation involvement are at a higher risk of loss. When performing surgery on molars with through-and-through furcation defects, elevating the flaps on both sides of the tooth may result in tissue wall loss, gingival recession, and exposure of the furcation entrance. This case report presents the Single Buccal Envelope Flap with Connective Tissue Graft (CTG) Wall Technique for the treatment of mandibular Class III furcation defects. We used a single-flap approach for the buccal side, while preserving the lingual side as an intact soft tissue wall. After thorough debridement of the furcation area, fibroblast growth factor-2 was first applied to the tooth surface and then mixed with autogenous bone, which was grafted into the defect. A CTG was placed on the buccal side, followed by buccal flap suturing. Preoperatively, the probing depths at the furcation sites were 7 mm and 9 mm on the buccal and lingual sides, respectively. At 12 months postoperatively, these were reduced to 4 mm and 3 mm, respectively. The radiographic comparison with preoperative images revealed bone regeneration within the defect area. Furthermore, the furcation entrance remained unexposed and stable during the 12-month follow-up period.

在支持牙周护理期间,涉及第三类分叉的牙齿有较高的丢失风险。在对有贯穿性分岔缺陷的磨牙进行手术时,抬高牙齿两侧的皮瓣可能导致组织壁丢失、牙龈萎缩和分岔入口暴露。本病例报告提出单颊包膜瓣结合结缔组织移植(CTG)壁技术治疗下颌骨III类功能缺损。我们对颊侧采用单瓣入路,同时保留舌侧完整的软组织壁。彻底清创后,先将成纤维细胞生长因子-2涂抹在牙表面,然后与自体骨混合,将自体骨移植到缺损处。在颊侧放置CTG,随后进行颊瓣缝合。术前颊侧和舌侧分岔处探探深度分别为7mm和9mm。在术后12个月,这些分别减少到4mm和3mm。x线片与术前图像比较显示缺损区域内骨再生。此外,在12个月的随访期间,分叉口保持未暴露和稳定。
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引用次数: 0
Outcomes of Periodontal Regenerative Surgery Performed by Periodontology Trainees. 牙周病学学员牙周再生手术的结果。
IF 1.1 Pub Date : 2025-11-14 DOI: 10.11607/prd.7713
Fatimah Alghareeb, Pegah Pasha, Mira Shah, Dhare Alshemmeri, Lorenzo Marini, Luigi Nibali

Aims: This prospectively-collected longitudinal service evaluation assessed the outcomes of periodontal regenerative surgery performed by periodontology trainees in the MClinDent program at Guy's Hospital, London. The primary aim was to evaluate 12-month clinical outcomes, with secondary aims to explore predictors of success and (reported separately) assess the feasibility of predicting defect morphology radiographically.

Materials and methods: Data from 173 intrabony defects in 133 patients (October 2020-May 2023) were analysed. Primary outcomes were pocket closure (PC; PPD ≤4 mm, no BoP) and composite outcome measure (COM; PC + CAL gain ≥3 mm). Descriptive and multilevel multivariate analyses were performed, with univariate analyses interpreted as exploratory.

Results: At 12 months, mean CAL gain was 2.78 mm, PPD reduction 3.27 mm, with PC in 58% and COM in 45% of sites. Radiographically, mean intrabony reduction was 3.3 mm, with ≥3 mm reduction in 52% of sites. Multivariate models identified full-mouth plaque score (p=0.024) and suprabony defect depth (p=0.036) as predictors of COM, and intrabony defect depth as predictor of PC (p=0.002).

Conclusion: Regenerative surgery performed by trainees achieved meaningful clinical and radiographic improvements, with outcomes comparable to published ranges but slightly less predictable than in specialist-led trials. Plaque control and defect morphology were key determinants of success, highlighting the importance of case selection and supportive care. The exploratory nature of predictor analyses, constrained by sample size and subgroup representation, underscores the need for validation in larger, controlled studies.

目的:这项前瞻性收集的纵向服务评估评估了伦敦盖伊医院麦克林登特项目牙周病学学员进行牙周再生手术的结果。主要目的是评估12个月的临床结果,次要目的是探索成功的预测因素,并评估影像学预测缺陷形态的可行性(单独报告)。材料与方法:对133例患者(2020年10月- 2023年5月)173例骨内缺损的数据进行分析。主要指标为口袋闭合(PC; PPD≤4mm,无BoP)和复合指标(COM; PC + CAL增益≥3mm)。进行了描述性和多变量分析,单变量分析被解释为探索性分析。结果:12个月时,平均CAL增加2.78 mm, PPD减少3.27 mm, PC占58%,COM占45%。x线摄影显示,平均骨内复位3.3 mm, 52%的部位复位≥3 mm。多变量模型表明,全口菌斑评分(p=0.024)和上颌骨缺损深度(p=0.036)是COM的预测因子,而骨内缺损深度是PC的预测因子(p=0.002)。结论:受训者进行的再生手术取得了有意义的临床和影像学改善,其结果与已发表的范围相当,但与专家主导的试验相比,其可预测性略低。斑块控制和缺陷形态是成功的关键决定因素,突出了病例选择和支持性护理的重要性。预测分析的探索性,受样本量和亚组代表性的限制,强调需要在更大的对照研究中进行验证。
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引用次数: 0
Staged Regenerative-Phenotype Modification Therapy for Multiple RT3 Gingival Recessions in Periodontally Compromised Anterior Mandibular Teeth: A Case Report. 针对牙周受损的下颌前牙多发性 RT3 牙龈退缩的分阶段再生表型修正疗法:病例报告。
IF 1.1 Pub Date : 2025-11-07 DOI: 10.11607/prd.7218
Taito Watanabe, Akira Hasuike, Yudai Ogawa, Shayan Barootchi, Shuichi Sato, Lorenzo Tavelli

This case report details the successful treatment of multiple recession type (RT) 3 gingival reces-sions in periodontally compromised mandibular anterior teeth with limited keratinized tissue. A 35-year-old man with stage III, grade C periodontitis underwent a two-stage intervention. Initially, a modification of the connective tissue graft (m-CTG) wall technique was used as part of phenotype modification therapy. The CTG acted as a protective 'wall,' securing space for periodontal regener-ation and thereby enhancing root coverage, soft tissue thickness, and keratinized mucosal width. Recombinant human fibroblast growth factor-2 and carbonate apatite promoted periodontal regen-eration. This procedure successfully facilitated periodontal regeneration, resulting in the transition from RT3 to RT2 gingival recession and achieving adequate keratinized mucosal width. Eighteen months later, the second surgery used a tunneled coronally advanced flap (TCAF) for root coverage. TCAF involved combining a coronally advanced flap and tunnel technique by elevating the trapezoi-dal surgical papilla and using a deepithelialized CTG inserted beneath the tunneled flap. Root con-ditioning with ethylenediaminetetraacetic acid and enamel matrix derivative gel application were performed. Consequently, the mean clinical attachment level gain was 5.3 mm, mean root coverage was 4.5 mm in height, and the gingival phenotype at the treated sites had improved at the 12-month follow-up. This staged approach addresses the challenges of treating RT3 gingival recession with promising outcomes.

我们报告了对角化组织有限、牙周受损的下颌前牙多发性牙龈退缩(RT)3 型的成功治疗。一名 35 岁的男子患有 III 期 C 级牙周炎,接受了两阶段干预。首先,作为表型改变疗法的一部分,采用了结缔组织移植(m-CTG)墙技术。结缔组织移植起到保护 "墙 "的作用,确保牙周再生的空间,提高牙根覆盖率、软组织厚度和角化粘膜宽度。重组人成纤维细胞生长因子-2 和碳酸盐磷灰石促进了牙周再生。这次手术成功地促进了牙周再生,使牙龈退缩从 RT3 过渡到 RT2,并获得了足够的角化粘膜宽度。18 个月后,第二次手术使用了隧道式冠状前移皮瓣(TCAF)进行牙根覆盖。隧道式牙冠前移皮瓣将牙冠前移皮瓣和隧道技术相结合,抬高梯形手术乳头,并在隧道式皮瓣下方插入去上皮的 CTG。使用乙二胺四乙酸进行牙根调节,并涂抹釉质基质衍生物凝胶。结果,平均 CAL 增量为 5.3 毫米,平均牙根覆盖高度为 4.5 毫米,治疗部位的牙龈表型在 12 个月的随访中得到了改善。这种分阶段的方法解决了治疗 RT3 牙龈退缩的难题,并取得了良好的效果。
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引用次数: 0
The Papilla Base CTG: A Novel Approach for Interdental Soft Tissue Reconstruction. 乳头基底 CTG:牙间隙软组织重建的新方法。
IF 1.1 Pub Date : 2025-11-07 DOI: 10.11607/prd.7346
Giovanni Zucchelli, Ilham Mounssif, Claudio Mazzotti, Valentina Bentivogli, Alexandra Rendon, Matteo Sangiorgi, Martina Stefanini

Impairment or loss of the interdental papilla is a common issue in patients with periodontal disease, leading to phonetic, functional, and esthetic concerns. Numerous techniques have been explored to reconstruct and regenerate interdental papillae, but consistent success remains challenging. This arti-cle presents a novel surgical approach that applies the principles of the connective tissue graft (CTG) wall technique to enhance papilla volume when interdental clinical attachment loss is present in the esthetic zone. The case of a 35-year-old woman with an RT3 recession defect associated with loss of interdental hard and soft tissues is discussed. The patient underwent a procedure involving palatal in-cisions, application of amelogenins, and a trapezoid-shaped CTG fixed at the base of the papilla under a coronally advanced flap. This approach aimed to stabilize the blood clot and prevent soft tissue col-lapse into the defect area, enhancing the position and volume of the interdental papilla. Results at the 6- and 12-month follow-ups indicated significant improvement in papilla appearance and complete root coverage. This case suggests that the modified CTG wall technique can effectively treat buccal and interdental gingival recessions associated with horizontal or infrabony defects. Further clinical trials are necessary to confirm these findings and establish the most effective approach for interdental papilla reconstruction.

牙间乳头受损或缺失是牙周病患者的常见问题,会导致语音、功能和美观方面的问题。人们已经探索了许多重建和再生牙间乳头的技术,但要取得一致的成功仍具有挑战性。本文介绍了一种新颖的手术方法,该方法应用结缔组织移植(CTG)壁技术的原理,在美学区域出现牙间临床附着丧失时增强乳头体积。本文讨论了一名 35 岁女性的病例,她的 RT3 衰退缺损伴有牙间硬组织和软组织的缺失。患者接受的手术包括腭切口、应用氨甲喋呤,以及在乳头基底固定一个梯形 CTG,并将其置于冠状推进瓣下。这种方法旨在稳定血凝块,防止软组织塌陷到缺损区,从而增强牙间乳头的位置和体积。6 个月和 12 个月的随访结果表明,乳头的外观有了明显改善,牙根也得到了完全覆盖。该病例表明,改良 CTG 壁技术可以有效治疗与水平或无骨性缺损相关的颊面和牙间龈凹陷。有必要进行进一步的临床试验来证实这些研究结果,并确定最有效的牙间乳头重建方法。
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引用次数: 0
Celebrating the 40th Birthday of a Legendary Surgical Approach: The Subepithelial Connective Tissue Graft Plus a Coronally Advanced Flap. 庆祝一种传奇手术方法诞生40周年:上皮下结缔组织移植物加冠状高级皮瓣。
IF 1.1 Pub Date : 2025-11-07 DOI: 10.11607/prd.2025.6.c
Leandro Chambrone, Gustavo Avila-Ortiz
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引用次数: 0
Farewell to Dr Oscar Gonzalez-Martin. 再见奥斯卡·冈萨雷斯·马丁博士。
IF 1.1 Pub Date : 2025-11-07 DOI: 10.11607/prd.2025.6.e
Christian W Haase
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引用次数: 0
The Double Subepithelial Connective Tissue Pedicle Graft Combined with an Interproximal- Buccal Tunneling Approach for Restoring Bilateral Missing Papillae: A Case Report. 双上皮下结缔组织基底移植结合近端-颊间隧道法修复双侧乳头缺失:病例报告。
IF 1.1 Pub Date : 2025-11-07 DOI: 10.11607/prd.7326
Maria das Graças Cruz Najar, Leandro Chambrone

This case report presents a papillary reconstructive surgical procedure based on the use of a double subepithelial connective tissue pedicle graft (SCTPG) in conjunction with a coronally advanced tunnel flap (CATF) for root coverage of gingival recession defects (GRDs) with interproximal tissue loss and adjacent collapsed papillae. Two GRDs (teeth 12 and 13; FDI numbering system) with interproximal tissue loss and collapsed papillae were treated by means of a bilaminar approach, based on the use of a palatal double SCTPG rotated and inserted into a palatal-buccal tunnel flap at the level of the mesial and distal papillae of the maxillary right lateral incisor, associated with a CATF. Seven months after surgery, complete root coverage was achieved in both GRDs. Concerning the reconstruction of tooth 12's papillae, the distance from the contact point to the tip of the distal and mesial papillae decreased from 5 to 2 mm and from 4 to 2 mm, respectively. Overall, the patient was highly satisfied with the outcome. Within the limits of this case report, it could be demonstrated that the double SCTPG + CATF promoted prominent clinical and esthetic improvements to the baseline conditions of both the GRDs and collapsed papillae.

本病例报告提出了一种基于双上皮下结缔组织蒂移植物(SCTPG)结合冠状隧道皮瓣(CATF)的乳头重建手术,用于龈退缩缺陷(GRDs)近端组织丢失和邻近乳头塌陷的根覆盖。两个GRDs(牙齿12和13;FDI编号系统)近端组织丢失和乳头塌陷,采用双层入路治疗,基于使用腭双SCTPG旋转并插入腭颊隧道皮瓣,位于上颌右侧切牙近中和远中乳头水平,并伴有CATF。术后7个月,两组grd均实现了完全的根覆盖。在牙齿12的乳头重建中,接触点到远端乳头尖和中端乳头尖的距离分别从5 mm和4 mm减少到2 mm。总体而言,患者对治疗结果非常满意。在本病例报告的范围内,可以证明双重SCTPG + CATF对GRDs和塌陷乳头的基线状况均有显著的临床和美学改善。
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引用次数: 0
A 37-Year Retrospective Assessment of Connective Tissue Grafting: What Have We Learned? A Case Report. 37年结缔组织移植回顾性评估:我们学到了什么?一个病例报告。
IF 1.1 Pub Date : 2025-11-07 DOI: 10.11607/prd.7744
Peter Cabrera, Gustavo Vicentis Oliveira Fernandes

This case report presents the 37-year follow-up results of a gingival recession (GR) treatment in the maxillary esthetic zone. In 1987, a healthy 20-year-old woman with a history of orthodontic treatment presented with a chief complaint of GR on the facial area of tooth 21 (FDI numbering system). There was no occlusal trauma, hypersensitivity, or parafunctional habit. Clinically, there was a 4-mm GR on the facial surface, classified as Miller class I (RT1), with a probing depth of 1 mm and no bleeding on probing. A partial-thickness flap was reflected around the teeth to be grafted. The donor site (palate) provided a subepithelial connective tissue graft (SCTG), as per the Langer and Langer protocol. A 2-mm-thick graft was harvested and surgically placed on the recipient site; the flap was then reposi-tioned. The patient was evaluated after 6 months (GR: -0.5 mm), 27 years (GR: 1.0 mm), and 37 years (GR: 1.5 mm). This was a successful long-term result. However, a relapse was noted, possibly exac-erbated by orthodontic treatment associated with the thin overall phenotype in both arches. SCTG is a safe and effective modality for long-term root coverage, demonstrating tissue stability, thickness gain, and complete root coverage within 6 months after the procedure. A relapse of approximately 1.5 mm was noted on the facial surface after 37 years.

目的:报告上颌美观区龈退缩治疗37年的随访结果。病例描述:1987年,一名健康的20岁女性,有正畸治疗史,主诉为面部9号区GR。无咬合创伤、过敏或功能异常习惯。临床见面表GR 4mm,分类为Miller’s Class I (RT1),探诊深度1mm,未见探诊出血。在待植牙周围反射部分厚度的皮瓣。根据Langer和Langer协议,供体部位(上颚)提供上皮下结缔组织移植物(CTG)。取2mm厚的移植物,手术放置于受体侧;然后重新定位皮瓣。患者分别在6个月(GR: -0.5mm)、27年(GR: 1.0mm)和37年(GR: 1.5mm)后进行评估。这是一个成功的长期结果。然而,复发被注意到,可能加剧了正畸治疗与薄的整体表型在两个弓。结论:SCTG是一种安全有效的长期根覆盖方式,在手术后6个月内表现出组织稳定性、厚度增加和完全的根覆盖。37年后,面部复发约1.5 mm。
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引用次数: 0
期刊
The International journal of periodontics & restorative dentistry
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