Efficacy of Verapamil Combined with Zinc Oxide for Anal Fissure Management

Abstract

Anal fissure are common causes of rectal bleeding; often necessitate effective local medicinal treatments to avoid surgical intervention. This study evaluates the efficacy of a novel combination therapy using verapamil and zinc oxide ointment for the management of chronic anal fissure. Verapamil, a calcium channel blocker, reduces sphincter pressure, while zinc oxide promotes healing through its anti-inflammatory properties. Conducted as a prospective randomized controlled trial, 65 patients were divided into three groups: a control group treated with Vaseline, a group treated with 15% verapamil ointment, and a group treated with 15% verapamil ointment and 10% zinc oxide ointment. Over a six-week period, the combination therapy group demonstrated significantly higher healing rates and pain relief compared to the other groups. The results suggest that verapamil combined with zinc oxide is a promising and effective treatment option for chronic anal fissures, with manageable side effects.