Influence the Distributions of Porosity on the Performance of Solubility Functions

Abstract

In this research , it was   possible to include the porosity distribution factor among the factors  affecting  solubility  instead  of the  surface area by  developing a mathematical mode which based  on  equations  Owtwald-Freundlich,  Gibbs-Thomson  and  Kaptay’s derivations which one of dependence on the surface area. Two sample of  ammonium perchlorate were applied , the first sample at normal state, and the second model which had changes were made to the surfaces of the particles. The results of the porosity tests for them  were  found  different.  Conducting  a  mathematical  analysis  of  the  results  and introducing  the  pore  distribution  variable.  The  surface  area  of  the  second  model increased by ( 26% ) in which the pore volume size between ( 30-4000) Å. The results indicate that the solubility increased in sample No. (2 ) by (12,28% ) and this is due to the increase in the pore distribution in the second model. in this case the larger surface area in the porosity distribution is the reason for the resulting increase in the solubility value, by the noting of the mechanism  dissolution process which adopted , that can provide an explanation for the increase in it. The  idea of pore distribution can be applied to enhance the quality of drugs through depending it's on the amount of solubility which required in order to perform its function well. For this, the aim of this research was to draw attention to the challenges of solubility measurement and to present new techniques and detection methods that provide more accurate results by introduce the concept of pore size distribution to the particle instead of radii and surface area. It has been applied on ammonium perchlorate and  determine the effective porosity distribution to obtain the best or required solubility based on the results obtained from studying the laboratory-wise  and applying the results to mathematical models that are derived for.