What If We Could Swallow Medicines Instead of Needing Painful Injections?

David J. Brayden, Sarah Gundy, Claire Riordan
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Abstract

People usually take medicines by swallowing a tablet or pill, but many important medicines cannot be taken by mouth. Vaccines, for example, must be injected using a needle and syringe. You might know people who have diabetes, a condition in which the body does not make enough of the hormone insulin. Insulin allows your cells to use the sugar in your blood for energy. People with diabetes must take insulin to be able to lower their blood sugar levels. Unfortunately, people cannot take insulin by mouth because the acid in the stomach will attack it like food. Insulin is also large and cannot cross the wall of the intestine to get into the blood, which is where it needs to go. Instead, people must take insulin by injecting it into the blood. But what if medicines, like insulin, could be designed so they could be swallowed instead of being injected?
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如果我们可以吞服药物,而不需要痛苦的注射,会怎样?
人们通常通过吞服药片或药丸来服药,但许多重要药物不能口服。例如,疫苗必须用针头和注射器注射。您可能认识一些糖尿病患者,他们的身体无法制造足够的胰岛素。胰岛素能让细胞利用血液中的糖分获取能量。糖尿病患者必须服用胰岛素才能降低血糖水平。遗憾的是,人们不能口服胰岛素,因为胃酸会像食物一样侵蚀胰岛素。胰岛素的体积也很大,无法穿过肠壁进入血液,而血液正是胰岛素需要进入的地方。因此,人们必须将胰岛素注射到血液中。但是,如果像胰岛素这样的药物可以设计成可以吞服而不是注射呢?
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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