Therapeutic aspects of mesenchymal stems cells in medulloblastoma therapy: A review of the current knowledge: MSCs for Medulloblastoma

IF 0.5 Q4 CLINICAL NEUROLOGY Activitas Nervosa Superior Rediviva Pub Date : 2024-07-07 DOI:10.31577/ansr.2024.66.1.2
Amir Modarresi Chahardehi, Mahdi Khorsand Ghaffari, Maryam Ashrafi, Reyhaneh Honardoost, Aryan Rezaee, Faezeh Jamshidi Goharrizi, Haniyeh Ghahremanpouran
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Abstract

Medulloblastoma (MB), the most common malignant brain tumor in children, presents a significant therapeutic challenge. Despite advancements in treatment regimens, particularly for recurrence and leptomeningeal spread, achieving long-term survival for MB patients remains elusive. Multimodal therapies, including radiation, chemotherapy, and extensive surgical, have improved survival rates; however, roughly one-third of patients still face an incurable disease. Integrating mesenchymal stem cells (MSCs) from various sources is increasingly explored in novel therapeutic strategies. Hence, this review aims to comprehensively examine the migratory potential and therapeutic efficacy of MSCs in the context of experimental MB models. While MSCs are emerging as innovative cell-based delivery vehicles, their specific therapeutic potential in MB treatment requires further investigation.
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间充质干细胞在髓母细胞瘤治疗中的治疗作用:现有知识综述:间充质干细胞治疗髓母细胞瘤
髓母细胞瘤(MB)是儿童中最常见的恶性脑肿瘤,给治疗带来了巨大挑战。尽管治疗方案取得了进步,尤其是针对复发和脑外膜扩散的治疗方案,但髓母细胞瘤患者实现长期生存仍然遥遥无期。包括放疗、化疗和大范围手术在内的多模式疗法提高了存活率,但仍有约三分之一的患者面临不治之症。整合各种来源的间充质干细胞(MSCs)用于新型治疗策略的探索日益增多。因此,本综述旨在全面研究间充质干细胞在实验性甲基溴模型中的迁移潜力和治疗效果。虽然间充质干细胞正在成为创新的细胞递送载体,但其在甲基溴治疗中的具体治疗潜力仍需进一步研究。
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