Interspecific cross-talk: The catalyst driving microbial biosynthesis of secondary metabolites

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-08-09 DOI:10.1016/j.biotechadv.2024.108420
Guihong Yu, Xiaoxuan Ge, Wanting Li, Linwei Ji, Song Yang
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Abstract

Microorganisms co-exist and co-evolve in nature, forming intricate ecological communities. The interspecies cross-talk within these communities creates and sustains their great biosynthetic potential, making them an important source of natural medicines and high-value-added chemicals. However, conventional investigations into microbial metabolites are typically carried out in pure cultures, resulting in the absence of specific activating factors and consequently causing a substantial number of biosynthetic gene clusters to remain silent. This, in turn, hampers the in-depth exploration of microbial biosynthetic potential and frequently presents researchers with the challenge of rediscovering compounds. In response to this challenge, the coculture strategy has emerged to explore microbial biosynthetic capabilities and has shed light on the study of cross-talk mechanisms. These elucidated mechanisms will contribute to a better understanding of complex biosynthetic regulations and offer valuable insights to guide the mining of secondary metabolites. This review summarizes the research advances in microbial cross-talk mechanisms, with a particular focus on the mechanisms that activate the biosynthesis of secondary metabolites. Additionally, the instructive value of these mechanisms for developing strategies to activate biosynthetic pathways is discussed. Moreover, challenges and recommendations for conducting in-depth studies on the cross-talk mechanisms are presented.

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种间交流:推动微生物次生代谢物生物合成的催化剂。
微生物在自然界中共存共生,形成了错综复杂的生态群落。这些群落中的种间交流创造并维持了巨大的生物合成潜力,使其成为天然药物和高附加值化学品的重要来源。然而,传统的微生物代谢物研究通常是在纯培养物中进行的,因此缺乏特定的激活因子,从而导致大量生物合成基因簇保持沉默。这反过来又阻碍了对微生物生物合成潜力的深入探索,并经常给研究人员带来重新发现化合物的挑战。为了应对这一挑战,出现了探索微生物生物合成能力的共培养策略,并为研究交叉作用机制提供了启示。这些机制的阐明将有助于更好地理解复杂的生物合成调控,并为指导次生代谢物的挖掘提供宝贵的见解。本综述总结了微生物交叉作用机制的研究进展,尤其侧重于激活次生代谢物生物合成的机制。此外,还讨论了这些机制对开发激活生物合成途径的策略的指导价值。此外,还提出了对交叉对话机制进行深入研究的挑战和建议。
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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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