Early-life body mass index and the risk of six cardiovascular diseases: A Mendelian Randomization study

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-08-12 DOI:10.1111/ijpo.13157

Bojun Zhou, Lianghao Zhu, Xia Du, Hua Meng

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Abstract

Background

Observational studies consistently indicate an association between early-life body mass index (BMI) and several cardiovascular diseases (CVDs). However, the causal relationship remains uncertain. The primary objective of this study was to assess the causal relationship between early-life BMI and six types of CVDs using the Mendelian Randomization (MR) approach.

Methods

The dataset for this study was derived from large-scale, summary-level Genome-Wide Association Studies. Specifically, the following datasets we used, early-life BMI (n = 61 111, age = 2–10), heart failure (HF) dataset (n = 977 323), atrial fibrillation (AF) dataset (n = 1 030 836), coronary artery disease (CAD) dataset (n = 184 305), peripheral artery disease (PAD) dataset (n = 243 060), deep venous thrombosis (DVT) dataset (n = 1 500 861) and myocardial infarction (MI) dataset (n = 638 000). Multiple MR methods were utilized to evaluate the causal relationship between exposure and outcomes, accompanied by sensitivity analysis.

Results

Early-life BMI positively correlates with the risk of developing the six distinct CVDs included in this study. Specifically, elevated BMI during childhood is associated with a 31.9% risk for HF (Odds ratio [OR] = 1.319, 95% CI [1.160 to 1.499], p = 2.33 × 10⁻⁵), an 18.3% risk for AF (R = 1.183, 95% CI [1.088 to 1.287], p = 8.22 × 10⁻⁵), an 14.8% risk for CAD (OR = 1.148, 95% CI [1.028 to 1.283], p = 1.47 × 10⁻²), a 40.5% risk for PAD (OR = 1.405, 95% CI [1.233 to 1.600], p = 3.10 × 10⁻⁷) and 12.0% risk for MI (OR = 1.120, 95% CI [1.017 to 1.234], p = 2.18 × 10⁻²). Interestingly, the risk for deep venous thrombosis only increased by 0.5% (OR = 1.005, 95% CI [1.001 to 1.008], p = 2.13 × 10⁻³).

Conclusion

Genetically inferred early-life BMI is significantly associated with six distinct CVDs. This indicates that elevated early-life BMI is a significant risk factor for multiple cardiovascular disorders.

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早年体重指数与六种心血管疾病的风险：孟德尔随机研究。

背景：观察性研究一致表明，生命早期的体重指数（BMI）与多种心血管疾病（CVDs）之间存在关联。然而，其因果关系仍不确定。本研究的主要目的是利用孟德尔随机化（MR）方法评估生命早期体重指数与六种心血管疾病之间的因果关系：本研究的数据集来自大规模、摘要级的全基因组关联研究。具体来说，我们使用了以下数据集：生命早期体重指数（n = 61 111，年龄 = 2-10）、心力衰竭（HF）数据集（n = 977 323）、心房颤动（AF）数据集（n = 1 030 836）、冠状动脉疾病（CAD）数据集（n = 184 305）、外周动脉疾病（PAD）数据集（n = 243 060）、深静脉血栓（DVT）数据集（n = 1 500 861）和心肌梗塞（MI）数据集（n = 638 000）。采用多种磁共振方法评估暴露与结果之间的因果关系，并进行敏感性分析：结果：生命早期的体重指数与本研究中包括的六种不同心血管疾病的发病风险呈正相关。CAD风险为14.8%（OR = 1.148，95% CI [1.028至1.283]，p = 1.47 × 10-2），PAD风险为40.5%（OR = 1.405，95% CI [1.233至1.600]，p = 3.10 × 10-7），MI风险为12.0%（OR = 1.120，95% CI [1.017至1.234]，p = 2.18 × 10-2）。有趣的是，深静脉血栓风险仅增加了 0.5%（OR = 1.005，95% CI [1.001 至 1.008]，p = 2.13 × 10-3）：结论：遗传推断的早年体重指数与六种不同的心血管疾病有显著相关性。这表明，早年体重指数升高是多种心血管疾病的重要风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.