Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses.

IF 8.4 2区 医学 Q1 IMMUNOLOGY Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI:10.1080/22221751.2024.2386136
Pallavi Singh, Pratap Vydyam, Tiffany Fang, Karel Estrada, Luis Miguel Gonzalez, Ricardo Grande, Madelyn Kumar, Sakshar Chakravarty, Vincent Berry, Vincent Ranwez, Bernard Carcy, Delphine Depoix, Sergio Sánchez, Emmanuel Cornillot, Steven Abel, Loic Ciampossin, Todd Lenz, Omar Harb, Alejandro Sanchez-Flores, Estrella Montero, Karine G Le Roch, Stefano Lonardi, Choukri Ben Mamoun
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Abstract

Babesiosis, caused by protozoan parasites of the genus Babesia, is an emerging tick-borne disease of significance for both human and animal health. Babesia parasites infect erythrocytes of vertebrate hosts where they develop and multiply rapidly to cause the pathological symptoms associated with the disease. The identification of new Babesia species underscores the ongoing risk of zoonotic pathogens capable of infecting humans, a concern amplified by anthropogenic activities and environmental changes. One such pathogen, Babesia MO1, previously implicated in severe cases of human babesiosis in the United States, was initially considered a subspecies of B. divergens, the predominant agent of human babesiosis in Europe. Here we report comparative multiomics analyses of B. divergens and B. MO1 that offer insight into their biology and evolution. Our analysis shows that despite their highly similar genomic sequences, substantial genetic and genomic divergence occurred throughout their evolution resulting in major differences in gene functions, expression and regulation, replication rates and susceptibility to antiparasitic drugs. Furthermore, both pathogens have evolved distinct classes of multigene families, crucial for their pathogenicity and adaptation to specific mammalian hosts. Leveraging genomic information for B. MO1, B. divergens, and other members of the Babesiidae family within Apicomplexa provides valuable insights into the evolution, diversity, and virulence of these parasites. This knowledge serves as a critical tool in preemptively addressing the emergence and rapid transmission of more virulent strains.

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通过多组学分析深入了解巴贝西亚原虫 MO1 和巴贝西亚原虫分歧者的进化、毒性和物种分化。
摘要 由巴贝斯虫属原生动物寄生虫引起的巴贝斯虫病是一种新出现的蜱媒疾病,对人类和动物健康都具有重要意义。巴贝西亚原虫感染脊椎动物宿主的红细胞,并在红细胞中迅速发育和繁殖,从而引起与该疾病相关的病理症状。巴贝西亚原虫新物种的发现凸显了能够感染人类的人畜共患病原体的持续风险,而人类活动和环境变化加剧了这种风险。其中一种病原体是巴贝西亚原虫 MO1,它曾与美国的严重人类巴贝西亚原虫病病例有牵连,最初被认为是巴贝西亚原虫的一个亚种,而巴贝西亚原虫是欧洲人类巴贝西亚原虫病的主要病原体。在此,我们报告了对 B. divergens 和 B. MO1 进行的多组学比较分析,以深入了解它们的生物学和进化情况。我们的分析表明,尽管它们的基因组序列高度相似,但在整个进化过程中发生了巨大的遗传和基因组差异,导致基因功能、表达和调控、复制率和对抗原药物的敏感性等方面存在重大差异。此外,这两种病原体都进化出了不同类别的多基因家族,这对它们的致病性和对特定哺乳动物宿主的适应性至关重要。利用 B. MO1、B. Divergens 和 Apicomplexa 中 Babesiidae 家族其他成员的基因组信息,可以深入了解这些寄生虫的进化、多样性和毒力。这些知识是先发制人地应对毒性更强的菌株的出现和快速传播的重要工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Emerging Microbes & Infections
Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY
CiteScore
26.20
自引率
2.30%
发文量
276
审稿时长
20 weeks
期刊介绍: Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.
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