Unlocking potential of zinc oxide nanoparticles in enhancing topical drug delivery

IF 5.45 Q1 Physics and Astronomy Nano-Structures & Nano-Objects Pub Date : 2024-08-24 DOI:10.1016/j.nanoso.2024.101302

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Abstract

This review explores the pivotal role of zinc oxide nanoparticles in advancing modern topical drug delivery. Delving into topical drug delivery systems, it addresses the significance, challenges, and current trends. The section on zinc oxide nanoparticles provides a comprehensive overview, encompassing their properties, synthesis methods, and characterization techniques, highlighting their unique advantages in drug delivery. The focal point of the review is the multifaceted application of zinc oxide nanoparticles in topical drug delivery, showcasing their effectiveness in anti-inflammatory treatments, psoriasis management, combating skin cancer, antibacterial interventions, and promoting wound healing. Intradermal application of zinc oxide nanoparticles demonstrated notable efficacy in diminishing skin infection, lowering bacterial burden, and alleviating inflammation, concurrently fostering enhancement in the structural integrity of the infected skin. To recapitulate the remarkable properties of zinc oxide nanoparticles, offer an excellent alternative for revolutionizing topical drug delivery. Their enhanced permeation, stability, and biocompatibility offer tremendous potential for improving therapeutic outcomes.

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挖掘氧化锌纳米颗粒在增强局部给药方面的潜力

这篇综述探讨了氧化锌纳米颗粒在推动现代局部给药方面的关键作用。它深入探讨了局部给药系统的意义、挑战和当前趋势。关于氧化锌纳米颗粒的部分提供了全面的概述，包括其特性、合成方法和表征技术，突出了其在给药方面的独特优势。综述的重点是氧化锌纳米颗粒在局部给药方面的多方面应用，展示了它们在抗炎治疗、牛皮癣治疗、抗击皮肤癌、抗菌干预和促进伤口愈合方面的有效性。纳米氧化锌颗粒的皮内应用在减轻皮肤感染、降低细菌负担和缓解炎症方面具有显著疗效，同时还能增强受感染皮肤的结构完整性。综上所述，氧化锌纳米粒子的显著特性为局部给药带来了革命性的变化。它们具有更强的渗透性、稳定性和生物相容性，为改善治疗效果提供了巨大的潜力。

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .